PMID- 19260143
OWN - NLM
STAT- MEDLINE
DCOM- 20090623
LR  - 20211203
IS  - 1332-8166 (Electronic)
IS  - 0353-9504 (Print)
IS  - 0353-9504 (Linking)
VI  - 50
IP  - 1
DP  - 2009 Feb
TI  - Ethnic differences in brain-derived neurotrophic factor Val66Met polymorphism in 
      Croatian and Korean healthy participants.
PG  - 43-8
AB  - AIM: To compare the frequency of alleles and genotypes in brain-derived 
      neurotrophic factor (BDNF) val66met polymorphism in ethnically homogenous 
      Caucasian (from Croatia) and ethnically homogenous Asian (from South Korea) 
      healthy participants, as inter-population differences in BDNF val66met may be 
      responsible for the divergent findings in genetic and association studies. 
      METHODS: BDNF val66met was genotyped in 800 (556 Croatian and 244 Korean) healthy 
      participants. Frequencies of alleles and genotypes were evaluated using a chi(2) 
      test. RESULTS: The frequencies for genotypes (chi(2)2=114.69; P<0.001) and 
      alleles (chi(2)1=120.07; P<0.001) between Korean and Croatian individuals 
      differed significantly, due to significantly lower (46.3% and 19.5%, P<0.001) 
      frequency of "Met" allele and significantly higher (53.7% and 80.5%, P<0.001) 
      frequency of "Val" allele in Croatian than in Korean participants. CONCLUSION: 
      The study found significant ethnic differences in BDNF val66met polymorphism. The 
      most frequent genotype among Korean participants was "Met/Val" and they had 
      similar distribution of "Met" and "Val" alleles. In contrast, the most frequent 
      genotype among Caucasian participants was "Val/Val" and they had different 
      distribution of "Met" and "Val" alleles. These ethnic differences require 
      matching participants for ethnicity in pharmacogenetic studies and in the studies 
      investigating genetic variations in neuropsychiatric disorders.
FAU - Pivac, Nela
AU  - Pivac N
AD  - Laboratory for Molecular Neuropsychiatry, Division of Molecular Medicine, Rudjer 
      Boskovic Institute, 10002 Zagreb, Croatia. npivac@irb.hr
FAU - Kim, Byungsu
AU  - Kim B
FAU - Nedic, Gordana
AU  - Nedic G
FAU - Joo, Yeon Ho
AU  - Joo YH
FAU - Kozaric-Kovacic, Dragica
AU  - Kozaric-Kovacic D
FAU - Hong, Jin Pyo
AU  - Hong JP
FAU - Muck-Seler, Dorotea
AU  - Muck-Seler D
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Croatia
TA  - Croat Med J
JT  - Croatian medical journal
JID - 9424324
RN  - 0 (Brain-Derived Neurotrophic Factor)
SB  - IM
MH  - Adult
MH  - Alleles
MH  - Brain-Derived Neurotrophic Factor/*genetics
MH  - Croatia
MH  - Ethnicity/genetics
MH  - Female
MH  - Gene Frequency/genetics
MH  - Genotype
MH  - *Health Status
MH  - Humans
MH  - Korea
MH  - Male
MH  - Polymorphism, Genetic/*genetics
PMC - PMC2657559
EDAT- 2009/03/05 09:00
MHDA- 2009/06/24 09:00
CRDT- 2009/03/05 09:00
PHST- 2009/03/05 09:00 [entrez]
PHST- 2009/03/05 09:00 [pubmed]
PHST- 2009/06/24 09:00 [medline]
AID - CroatMedJ_50_0043 [pii]
AID - 10.3325/cmj.2009.50.43 [doi]
PST - ppublish
SO  - Croat Med J. 2009 Feb;50(1):43-8. doi: 10.3325/cmj.2009.50.43.