PMID- 19261457
OWN - NLM
STAT- MEDLINE
DCOM- 20090605
LR  - 20220331
IS  - 1879-0410 (Electronic)
IS  - 0955-0674 (Linking)
VI  - 21
IP  - 2
DP  - 2009 Apr
TI  - mTOR and the control of whole body metabolism.
PG  - 209-18
LID - 10.1016/j.ceb.2009.01.024 [doi]
AB  - Mammalian Target of Rapamycin (mTOR) is a highly conserved protein kinase that 
      functions as part of two distinct multiprotein complexes to regulate growth and 
      metabolism. This review describes the most important recent advances in the mTOR 
      signaling field. In addition, we provide an overview on the functions of mTOR in 
      different organs, with a special focus on the role of mTOR in whole body energy 
      metabolism.
FAU - Polak, Pazit
AU  - Polak P
AD  - Biozentrum, University of Basel, Basel, Switzerland.
FAU - Hall, Michael N
AU  - Hall MN
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20090302
PL  - England
TA  - Curr Opin Cell Biol
JT  - Current opinion in cell biology
JID - 8913428
RN  - 0 (CRTC2 protein, human)
RN  - 0 (Multiprotein Complexes)
RN  - 0 (Proteins)
RN  - 0 (Transcription Factors)
RN  - EC 2.7.- (Protein Kinases)
RN  - EC 2.7.1.1 (MTOR protein, human)
RN  - EC 2.7.11.1 (Mechanistic Target of Rapamycin Complex 1)
RN  - EC 2.7.11.1 (TOR Serine-Threonine Kinases)
SB  - IM
MH  - Animals
MH  - *Energy Metabolism
MH  - Humans
MH  - Mechanistic Target of Rapamycin Complex 1
MH  - Multiprotein Complexes
MH  - Phenotype
MH  - Protein Kinases/*metabolism
MH  - Proteins
MH  - Signal Transduction/*physiology
MH  - TOR Serine-Threonine Kinases
MH  - Transcription Factors/metabolism
RF  - 94
EDAT- 2009/03/06 09:00
MHDA- 2009/06/06 09:00
CRDT- 2009/03/06 09:00
PHST- 2009/01/09 00:00 [received]
PHST- 2009/01/15 00:00 [accepted]
PHST- 2009/03/06 09:00 [entrez]
PHST- 2009/03/06 09:00 [pubmed]
PHST- 2009/06/06 09:00 [medline]
AID - S0955-0674(09)00035-0 [pii]
AID - 10.1016/j.ceb.2009.01.024 [doi]
PST - ppublish
SO  - Curr Opin Cell Biol. 2009 Apr;21(2):209-18. doi: 10.1016/j.ceb.2009.01.024. Epub 
      2009 Mar 2.