PMID- 19261747
OWN - NLM
STAT- MEDLINE
DCOM- 20090508
LR  - 20220311
IS  - 1549-5477 (Electronic)
IS  - 0890-9369 (Print)
IS  - 0890-9369 (Linking)
VI  - 23
IP  - 6
DP  - 2009 Mar 15
TI  - Inactivation of p53 and Pten promotes invasive bladder cancer.
PG  - 675-80
LID - 10.1101/gad.1772909 [doi]
AB  - Although bladder cancer represents a serious health problem worldwide, relevant 
      mouse models for investigating disease progression or therapeutic targets have 
      been lacking. We show that combined deletion of p53 and Pten in bladder 
      epithelium leads to invasive cancer in a novel mouse model. Inactivation of p53 
      and PTEN promotes tumorigenesis in human bladder cells and is correlated with 
      poor survival in human tumors. Furthermore, the synergistic effects of p53 and 
      Pten deletion are mediated by deregulation of mammalian target of rapamycin 
      (mTOR) signaling, consistent with the ability of rapamycin to block bladder 
      tumorigenesis in preclinical studies. Our integrated analyses of mouse and human 
      bladder cancer provide a rationale for investigating mTOR inhibition for 
      treatment of patients with invasive disease.
FAU - Puzio-Kuter, Anna M
AU  - Puzio-Kuter AM
AD  - Department of Urology, Columbia University, College of Physicians and Surgeons, 
      New York, New York 10032, USA.
FAU - Castillo-Martin, Mireia
AU  - Castillo-Martin M
FAU - Kinkade, Carolyn W
AU  - Kinkade CW
FAU - Wang, Xi
AU  - Wang X
FAU - Shen, Tian Huai
AU  - Shen TH
FAU - Matos, Tulio
AU  - Matos T
FAU - Shen, Michael M
AU  - Shen MM
FAU - Cordon-Cardo, Carlos
AU  - Cordon-Cardo C
FAU - Abate-Shen, Cory
AU  - Abate-Shen C
LA  - eng
GR  - P50 CA091846/CA/NCI NIH HHS/United States
GR  - CA1106625/CA/NCI NIH HHS/United States
GR  - R01 CA115985/CA/NCI NIH HHS/United States
GR  - P01 CA087497/CA/NCI NIH HHS/United States
GR  - P30 CA013696/CA/NCI NIH HHS/United States
GR  - P01 CA87497/CA/NCI NIH HHS/United States
GR  - P30 CA13696/CA/NCI NIH HHS/United States
GR  - U01 CA084294/CA/NCI NIH HHS/United States
GR  - CA115985/CA/NCI NIH HHS/United States
GR  - P50 CA91846/CA/NCI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20090304
PL  - United States
TA  - Genes Dev
JT  - Genes & development
JID - 8711660
RN  - 0 (Tumor Suppressor Protein p53)
RN  - EC 2.7.- (Protein Kinases)
RN  - EC 2.7.1.1 (MTOR protein, human)
RN  - EC 2.7.1.1 (mTOR protein, mouse)
RN  - EC 2.7.11.1 (TOR Serine-Threonine Kinases)
RN  - EC 3.1.3.67 (PTEN Phosphohydrolase)
RN  - EC 3.1.3.67 (PTEN protein, human)
RN  - EC 3.1.3.67 (Pten protein, mouse)
SB  - IM
CIN - Genes Dev. 2009 Mar 15;23(6):655-9. PMID: 19299556
MH  - Animals
MH  - Carcinoma, Transitional Cell/genetics/metabolism/*pathology
MH  - *Cell Transformation, Neoplastic
MH  - *Disease Models, Animal
MH  - Humans
MH  - Lymphatic Metastasis
MH  - Male
MH  - Mice
MH  - Mice, Nude
MH  - Mice, Transgenic
MH  - Neoplasm Invasiveness
MH  - PTEN Phosphohydrolase/genetics/*metabolism
MH  - Protein Kinases/physiology
MH  - Rats
MH  - Signal Transduction
MH  - TOR Serine-Threonine Kinases
MH  - Tumor Suppressor Protein p53/genetics/*metabolism
MH  - Urinary Bladder Neoplasms/genetics/metabolism/*pathology
PMC - PMC2661614
EDAT- 2009/03/06 09:00
MHDA- 2009/05/09 09:00
PMCR- 2009/09/15
CRDT- 2009/03/06 09:00
PHST- 2009/03/06 09:00 [entrez]
PHST- 2009/03/06 09:00 [pubmed]
PHST- 2009/05/09 09:00 [medline]
PHST- 2009/09/15 00:00 [pmc-release]
AID - gad.1772909 [pii]
AID - 10.1101/gad.1772909 [doi]
PST - ppublish
SO  - Genes Dev. 2009 Mar 15;23(6):675-80. doi: 10.1101/gad.1772909. Epub 2009 Mar 4.