PMID- 19262380
OWN - NLM
STAT- MEDLINE
DCOM- 20100222
LR  - 20090324
IS  - 1473-656X (Electronic)
IS  - 1040-872X (Linking)
VI  - 21
IP  - 2
DP  - 2009 Apr
TI  - Herpes simplex virus: incidence of neonatal herpes simplex virus, maternal 
      screening, management during pregnancy, and HIV.
PG  - 124-30
LID - 10.1097/GCO.0b013e3283294840 [doi]
AB  - PURPOSE OF REVIEW: Neonatal herpes simplex virus infection is often severe, if 
      not fatal. What is our understanding of the epidemiology of this disease? How is 
      it diagnosed? Would maternal screening for herpes simplex virus-2 (HSV-2) in 
      pregnancy make a difference? Does maternal HSV alter transmission of HIV 
      vertically or horizontally or both? These questions continue to be pursued and 
      unfortunately, there are few clear answers. RECENT FINDINGS: A nationally 
      reportable incidence and case definition of neonatal herpes simplex virus is 
      desirable but not yet in effect. Maternal screening for HSV during pregnancy is 
      becoming prevalent but not supported by any national committee or recommendation. 
      Several lines of research have demonstrated HSV expression facilitates HIV 
      transmission. Recently, HSV suppression has been attempted to decrease horizontal 
      transmission of HIV. SUMMARY: Neonatal herpes simplex virus infection is a rare 
      and serious neonatal illness. The true burden of disease is uncertain. Several 
      recent retrospectively determined incidences identify a case rate of about one 
      per eight thousand live births. HSV reactivation occurs more often than 
      previously thought. Current prophylactic HSV strategies do not decrease 
      horizontal or vertical transmission of HIV-1.
FAU - Roberts, Scott
AU  - Roberts S
AD  - Department of Obstetrics and Gynecology, University of Texas Southwestern Medical 
      Center, Dallas, Texas 75390-9032, USA. scott.roberts@utsouthwestern.edu
LA  - eng
PT  - Journal Article
PT  - Review
PL  - England
TA  - Curr Opin Obstet Gynecol
JT  - Current opinion in obstetrics & gynecology
JID - 9007264
RN  - 0 (Antiviral Agents)
SB  - IM
MH  - Antiviral Agents/therapeutic use
MH  - Female
MH  - HIV Infections/complications/diagnosis/*epidemiology
MH  - Herpes Simplex/complications/diagnosis/*epidemiology
MH  - Humans
MH  - Infant, Newborn
MH  - Mass Screening
MH  - Obstetrics/*methods
MH  - Pregnancy
MH  - Pregnancy Complications, Infectious/diagnosis/*epidemiology
MH  - Research Design
MH  - Simplexvirus/*metabolism
RF  - 39
EDAT- 2009/03/06 09:00
MHDA- 2010/02/23 06:00
CRDT- 2009/03/06 09:00
PHST- 2009/03/06 09:00 [entrez]
PHST- 2009/03/06 09:00 [pubmed]
PHST- 2010/02/23 06:00 [medline]
AID - 10.1097/GCO.0b013e3283294840 [doi]
PST - ppublish
SO  - Curr Opin Obstet Gynecol. 2009 Apr;21(2):124-30. doi: 
      10.1097/GCO.0b013e3283294840.