PMID- 19262581
OWN - NLM
STAT- MEDLINE
DCOM- 20091221
LR  - 20161125
IS  - 1476-5527 (Electronic)
IS  - 0950-9240 (Linking)
VI  - 23
IP  - 11
DP  - 2009 Nov
TI  - Blood pressure levels, left ventricular mass and function are correlated with 
      left atrial volume in mild to moderate hypertensive patients.
PG  - 743-50
LID - 10.1038/jhh.2009.15 [doi]
AB  - Arterial hypertension is associated with an increased risk of atrial fibrillation 
      (AF), and leads to a pronounced increase in morbidity and mortality. Left atrial 
      volume (LAV) is an important prognostic marker in the older populations. The aim 
      of our study was to identify the clinical and echocardiographic determinants of 
      LAV in middle-aged (<70 years old) essential hypertensive patients.We evaluated 
      cardiac structure and function in 458 patients, 394 treated and untreated mild to 
      moderate essential hypertensives patients (mean+/-s.d. age 48.4+/-11.1 years) 
      with no associated clinical condition and 64 normotensive control participants 
      (age 45.7+/-12.8 years; P=0.12). A multivariate analysis was performed to 
      calculate the relative weight of each of the variables considered able to predict 
      LAV. The LAV index (LAVi) was significantly increased in the essential 
      hypertensive group vs the control group and was significantly dependent on blood 
      pressure levels (SBP and DBP, P<0.05 for both) and body mass index (BMI) 
      (P<0.0001). Considering the left ventricular (LV) variables, the LV mass index 
      (LVMI) (R(2)=0.19, P<0.001) and LAV were increased in essential hypertensive 
      patients with left ventricular hypertrophy (LVH), and patients with enlarged LAV 
      showed lower systolic and diastolic function and an increased LVMI. The LAVi is 
      dependent on blood pressure levels and anthropometric variables (age and BMI). 
      Further structural (LVMI) and functional (systolic and diastolic) variables are 
      related to the LAVi; LVMI is the most important variable associated with LAV in 
      mild to moderate essential hypertensive adult patients. These findings highlight 
      the importance of left atrium evaluation in adult, relatively young, essential 
      hypertensive patients.
FAU - Milan, A
AU  - Milan A
AD  - Hypertension Unit, Department of Medicine and Experimental Oncology, Division of 
      Internal Medicine, University of Torino, Torino, Italy. alby.milan@libero.it
FAU - Caserta, M A
AU  - Caserta MA
FAU - Dematteis, A
AU  - Dematteis A
FAU - Naso, D
AU  - Naso D
FAU - Pertusio, A
AU  - Pertusio A
FAU - Magnino, C
AU  - Magnino C
FAU - Puglisi, E
AU  - Puglisi E
FAU - Rabbia, F
AU  - Rabbia F
FAU - Pandian, N G
AU  - Pandian NG
FAU - Mulatero, P
AU  - Mulatero P
FAU - Veglio, F
AU  - Veglio F
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20090305
PL  - England
TA  - J Hum Hypertens
JT  - Journal of human hypertension
JID - 8811625
RN  - 0 (Antihypertensive Agents)
SB  - IM
MH  - Adult
MH  - Age Factors
MH  - Antihypertensive Agents/therapeutic use
MH  - Atrial Fibrillation/diagnostic imaging/*etiology/physiopathology
MH  - *Blood Pressure
MH  - Body Mass Index
MH  - Case-Control Studies
MH  - Echocardiography, Doppler
MH  - Heart Atria/diagnostic imaging
MH  - Heart Ventricles/diagnostic imaging/*physiopathology
MH  - Humans
MH  - Hypertension/complications/diagnostic imaging/drug therapy/*physiopathology
MH  - Hypertrophy, Left Ventricular/etiology/physiopathology
MH  - Linear Models
MH  - Middle Aged
MH  - Predictive Value of Tests
MH  - Risk Assessment
MH  - Risk Factors
MH  - Severity of Illness Index
MH  - *Ventricular Function, Left
EDAT- 2009/03/06 09:00
MHDA- 2009/12/22 06:00
CRDT- 2009/03/06 09:00
PHST- 2009/03/06 09:00 [entrez]
PHST- 2009/03/06 09:00 [pubmed]
PHST- 2009/12/22 06:00 [medline]
AID - jhh200915 [pii]
AID - 10.1038/jhh.2009.15 [doi]
PST - ppublish
SO  - J Hum Hypertens. 2009 Nov;23(11):743-50. doi: 10.1038/jhh.2009.15. Epub 2009 Mar 
      5.