PMID- 19264117
OWN - NLM
STAT- MEDLINE
DCOM- 20101105
LR  - 20131121
IS  - 1873-6815 (Electronic)
IS  - 0531-5565 (Linking)
VI  - 44
IP  - 6-7
DP  - 2009 Jun-Jul
TI  - Reserpine ameliorates Abeta toxicity in the Alzheimer's disease model in 
      Caenorhabditis elegans.
PG  - 462-6
LID - 10.1016/j.exger.2009.02.010 [doi]
AB  - Earlier we have reported that reserpine, an antihypertensive drug, known to 
      downregulate biogenic amines through inhibition of the vesicular monoamine 
      transporter (VMAT), increases longevity of Caenorhabditis elegans with a high 
      quality of life, namely, enhanced and prolonged mobility (Srivastava et al., 
      2008). As neurodegenerative diseases are of adult onset, we addressed the 
      protective ability of reserpine against neurodegenerative diseases, especially 
      Alzheimer's disease (AD). In the well established AD model in C. elegans, Amyloid 
      beta (Abeta) is expressed in the muscles and Abeta toxicity is manifested as 
      paralysis (Link, 1995). In this model, reserpine significantly delayed paralysis 
      and increased the longevity. In addition, reserpine provided thermotolerance, but 
      interestingly the Abeta transcript and expression levels remains grossly 
      unchanged.
FAU - Arya, Upasna
AU  - Arya U
AD  - Department of Biological Sciences and Bioengineering, Indian Institute of 
      Technology, Kanpur 208016, India.
FAU - Dwivedi, Hemalata
AU  - Dwivedi H
FAU - Subramaniam, Jamuna R
AU  - Subramaniam JR
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20090303
PL  - England
TA  - Exp Gerontol
JT  - Experimental gerontology
JID - 0047061
RN  - 0 (Amyloid beta-Peptides)
RN  - 0 (Antihypertensive Agents)
RN  - 8B1QWR724A (Reserpine)
SB  - IM
MH  - Alzheimer Disease/*drug therapy
MH  - Amyloid beta-Peptides/*drug effects/metabolism
MH  - Animals
MH  - Antihypertensive Agents/*pharmacology
MH  - Caenorhabditis elegans
MH  - Longevity
MH  - Reserpine/*pharmacology
EDAT- 2009/03/07 09:00
MHDA- 2010/11/06 06:00
CRDT- 2009/03/07 09:00
PHST- 2008/12/01 00:00 [received]
PHST- 2009/02/17 00:00 [revised]
PHST- 2009/02/20 00:00 [accepted]
PHST- 2009/03/07 09:00 [entrez]
PHST- 2009/03/07 09:00 [pubmed]
PHST- 2010/11/06 06:00 [medline]
AID - S0531-5565(09)00032-1 [pii]
AID - 10.1016/j.exger.2009.02.010 [doi]
PST - ppublish
SO  - Exp Gerontol. 2009 Jun-Jul;44(6-7):462-6. doi: 10.1016/j.exger.2009.02.010. Epub 
      2009 Mar 3.