PMID- 19265087
OWN - NLM
STAT- MEDLINE
DCOM- 20090409
LR  - 20240313
IS  - 1931-3543 (Electronic)
IS  - 0012-3692 (Print)
IS  - 0012-3692 (Linking)
VI  - 135
IP  - 3
DP  - 2009 Mar
TI  - Self-reported symptoms of depression and memory dysfunction in survivors of ARDS.
PG  - 678-687
LID - S0012-3692(09)60194-X [pii]
LID - 10.1378/chest.08-0974 [doi]
AB  - BACKGROUND: Survivors of ARDS have well documented physical limitations, but 
      psychological effects are less clear. We determined the prevalence of 
      self-reported depression and memory dysfunction in ARDS survivors. METHODS: Six 
      to 48 (median 22) months after ICU discharge, we administered instruments 
      assessing depression symptoms (Beck Depression Inventory-II [BDI-II]) and memory 
      dysfunction (Memory Assessment Clinics Self-Rating Scale [MAC-S]) to 82 ARDS 
      patients who were enrolled in a prospective cohort study in four 
      university-affiliated ICUs. RESULTS: Sixty-one (74%), 64 (78%), and 61 (74%) 
      patients fully completed the BDI-II, MAC-S (Ability subscale), and MAC-S 
      (Frequency of Occurrence subscale) instruments. Responders (similar to 
      nonresponders) were young (median 42 years, interquartile range [IQR] 35 to 56), 
      with high admission illness severity and organ dysfunction. The median BDI-II 
      score was 12 (IQR 5 to 25). Twenty-five (41%) patients reported moderate-severe 
      depression symptoms and were less likely to return to work than those with 
      minimal-mild symptoms (8/25 [32%] vs 25/36 [69%]; p = 0.005). Median MAC-S 
      (Ability) and MAC-S (Frequency of Occurrence) scores were 76 (IQR 61 to 93) and 
      91 (IQR 77 to 102), respectively; 8%, 16%, and 20% scored > 2, > 1.5, and > 1 
      SD(s), respectively, below age-adjusted population norms for each subscale. 
      BDI-II and MAC-S scores were negatively correlated (Spearman coefficient -0.58 
      and -0.50 for Ability and Frequency of Occurrence subscales, respectively; p < 
      0.0001). Univariable analyses showed no demographic or illness-severity 
      predictors of BDI-II (including the Cognitive subscale) or MAC-S (both 
      subscales); results were similar when restricted to patients whose primary 
      language was English. CONCLUSIONS: ARDS survivors report a high prevalence of 
      depression symptoms and a lower prevalence of memory dysfunction 6 to 48 months 
      after ICU discharge. Depression symptoms may hinder the return to work, or 
      patients may report these symptoms because of inability to re-enter the 
      workforce.
FAU - Adhikari, Neill K J
AU  - Adhikari NKJ
AD  - Interdepartmental Division of Critical Care and Department of Medicine, 
      University of Toronto, Toronto, ON, Canada. Electronic address: 
      neill.adhikari@utoronto.ca.
FAU - McAndrews, Mary Pat
AU  - McAndrews MP
AD  - Krembil Neuroscience Program, University Health Network, Toronto, ON, Canada.
FAU - Tansey, Catherine M
AU  - Tansey CM
AD  - Medical-Surgical Intensive Care Unit, University Health Network, Toronto, ON, 
      Canada.
FAU - Matte, Andrea
AU  - Matte A
AD  - Medical-Surgical Intensive Care Unit, University Health Network, Toronto, ON, 
      Canada.
FAU - Pinto, Ruxandra
AU  - Pinto R
AD  - Department of Critical Care Medicine, Sunnybrook Health Sciences Centre, Toronto, 
      ON, Canada.
FAU - Cheung, Angela M
AU  - Cheung AM
AD  - Department of Medicine, University of Toronto, Toronto, ON, Canada.
FAU - Diaz-Granados, Natalia
AU  - Diaz-Granados N
AD  - Women's Health Program, University Health Network, Toronto, ON, Canada.
FAU - Barr, Aiala
AU  - Barr A
AD  - Department of Public Health Sciences, University of Toronto, Toronto, ON, Canada.
FAU - Herridge, Margaret S
AU  - Herridge MS
AD  - Interdepartmental Division of Critical Care and Department of Medicine, 
      University of Toronto, Toronto, ON, Canada.
LA  - eng
GR  - 44917/CAPMC/CIHR/Canada
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Chest
JT  - Chest
JID - 0231335
SB  - IM
MH  - APACHE
MH  - Adult
MH  - Aged
MH  - Depressive Disorder/*etiology
MH  - Female
MH  - Humans
MH  - Male
MH  - Memory Disorders/*etiology
MH  - Middle Aged
MH  - Respiratory Distress Syndrome/*psychology
MH  - Self-Assessment
MH  - Surveys and Questionnaires
PMC - PMC5233444
MID - CAMS894
EDAT- 2009/03/07 09:00
MHDA- 2009/04/10 09:00
PMCR- 2017/01/12
CRDT- 2009/03/07 09:00
PHST- 2009/03/07 09:00 [entrez]
PHST- 2009/03/07 09:00 [pubmed]
PHST- 2009/04/10 09:00 [medline]
PHST- 2017/01/12 00:00 [pmc-release]
AID - S0012-3692(09)60194-X [pii]
AID - 10.1378/chest.08-0974 [doi]
PST - ppublish
SO  - Chest. 2009 Mar;135(3):678-687. doi: 10.1378/chest.08-0974.