PMID- 19265361
OWN - NLM
STAT- MEDLINE
DCOM- 20090818
LR  - 20090306
IS  - 1529-7535 (Print)
IS  - 1529-7535 (Linking)
VI  - 10
IP  - 2
DP  - 2009 Mar
TI  - Life-threatening human herpes virus-6 infection in early childhood: presenting 
      symptom of a primary immunodeficiency?
PG  - e16-8
LID - 10.1097/PCC.0b013e31819bb956 [doi]
AB  - OBJECTIVE: To report two previously healthy children with a life-threatening 
      course of human herpes virus type 6 (HHV-6) infection and prolonged pediatric 
      intensive care treatment. DESIGN: Case reports. SETTING: A 16 bed pediatric 
      intensive care unit at a tertiary care children's hospital. PATIENTS: Two 
      children with life-threatening HHV-6 disease. INTERVENTIONS: Both children were 
      mechanically ventilated because of respiratory failure. A detailed viral and 
      immunologic workup was performed and treatment with antiviral medication started. 
      MEASUREMENTS: Polymerase chain reaction assays of plasma, cerebrospinal fluid, 
      bronchoalveolar lavage, and lung biopsies yielded HHV-6 in both patients. 
      Immunophenotyping and lymphocyte stimulation tests with both mitogens and 
      antigens indicated an immunodeficiency in both patients. CONCLUSION: HHV-6 
      infection should be considered in infants and young children with respiratory 
      failure or meningo-encephalitis without clear causative agent or failure to 
      respond to empirical treatment. A thorough immunologic workup and early start 
      with antiviral therapy in any patient with a life-threatening course of HHV-6 
      infection is mandatory, because a severe HHV-6 infection can be the first 
      indication of a primary immunodeficiency.
FAU - Hennus, Marije P
AU  - Hennus MP
AD  - Department of Pediatric Intensive Care, Wilhelmina Children's Hospital, 
      University Medical Center Utrecht, Utrecht, The Netherlands. 
      m.p.hennus@umcutrecht.nl
FAU - van Montfrans, Joris M
AU  - van Montfrans JM
FAU - van Vught, Adrianus J
AU  - van Vught AJ
FAU - Tesselaar, Kiki
AU  - Tesselaar K
FAU - Boelens, Jaap-Jan
AU  - Boelens JJ
FAU - Jansen, Nicolaas J
AU  - Jansen NJ
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - United States
TA  - Pediatr Crit Care Med
JT  - Pediatric critical care medicine : a journal of the Society of Critical Care 
      Medicine and the World Federation of Pediatric Intensive and Critical Care 
      Societies
JID - 100954653
RN  - 0 (DNA, Viral)
SB  - IM
MH  - Bronchoalveolar Lavage Fluid
MH  - Child, Preschool
MH  - DNA, Viral/analysis
MH  - Female
MH  - Herpesvirus 6, Human/genetics/*isolation & purification
MH  - Humans
MH  - Immunologic Deficiency Syndromes/*physiopathology
MH  - Intensive Care Units, Pediatric
MH  - Male
MH  - Polymerase Chain Reaction
MH  - Roseolovirus Infections/*diagnosis/immunology/virology
MH  - Severity of Illness Index
EDAT- 2009/03/07 09:00
MHDA- 2009/08/19 09:00
CRDT- 2009/03/07 09:00
PHST- 2009/03/07 09:00 [entrez]
PHST- 2009/03/07 09:00 [pubmed]
PHST- 2009/08/19 09:00 [medline]
AID - 00130478-200903000-00035 [pii]
AID - 10.1097/PCC.0b013e31819bb956 [doi]
PST - ppublish
SO  - Pediatr Crit Care Med. 2009 Mar;10(2):e16-8. doi: 10.1097/PCC.0b013e31819bb956.