PMID- 1926585 OWN - NLM STAT- MEDLINE DCOM- 19911118 LR - 20150505 IS - 0201-8470 (Print) IS - 0201-8470 (Linking) VI - 63 IP - 3 DP - 1991 May-Jun TI - [Glutamate decarboxylase and GABA transaminase activity in the mitochondrial fraction of the dog brain limbic system during postnatal development]. PG - 36-40 AB - Overall glutamate decarboxylase (GDCase) activity in the initial mitochondrial fraction of the limbic structure is found to be regionally different it increases from the moment of birth up to 1 year, the midbrain reticular formation (RF), where the enzyme activity in the mitochondrial decreases in pups aged 3 month and reincreases in 1 year old dogs being the exception. Overall GABA-transaminase (GABA-T-ase) activity reaches the "adult" level and is the highest: in the hypothalamic and hippocampal mitochondria on the 1st postnatal day; in the limbic cortex (l1 and l2 fields), amygdala and midbrain RF--on the 12-16th postnatal days. During the period from 12-16 postnatal days up to the age of 1 year GABA-T-ase activity in the dog limbic system decreases reliably. FAU - Faradzhev, A N AU - Faradzhev AN LA - rus PT - English Abstract PT - Journal Article TT - Glutamatdekarboksilaznaia i GAMK-transaminaznaia aktivnost' v mitokhondrial'noi fraktsii struktur limbicheskoi sistemy mozga sobak v postnatal'nom ontogeneze. PL - Ukraine TA - Ukr Biokhim Zh (1978) JT - Ukrainskii biokhimicheskii zhurnal (1978) JID - 7804246 RN - EC 2.6.1.19 (4-Aminobutyrate Transaminase) RN - EC 4.1.1.15 (Glutamate Decarboxylase) SB - IM MH - 4-Aminobutyrate Transaminase/*metabolism MH - Aging/metabolism MH - Animals MH - Dogs MH - Glutamate Decarboxylase/*metabolism MH - Limbic System/*enzymology/growth & development MH - Mitochondria/enzymology EDAT- 1991/05/01 00:00 MHDA- 1991/05/01 00:01 CRDT- 1991/05/01 00:00 PHST- 1991/05/01 00:00 [pubmed] PHST- 1991/05/01 00:01 [medline] PHST- 1991/05/01 00:00 [entrez] PST - ppublish SO - Ukr Biokhim Zh (1978). 1991 May-Jun;63(3):36-40.