PMID- 19267954
OWN - NLM
STAT- MEDLINE
DCOM- 20091113
LR  - 20131121
IS  - 1475-2662 (Electronic)
IS  - 0007-1145 (Linking)
VI  - 102
IP  - 6
DP  - 2009 Sep
TI  - The addition of monosodium glutamate and inosine monophosphate-5 to high-protein 
      meals: effects on satiety, and energy and macronutrient intakes.
PG  - 929-37
LID - 10.1017/S0007114509297212 [doi]
AB  - In a fed and orally stimulated state, whether the addition of monosodium 
      glutamate (MSG) (alone or in combination with inosine monophosphate-5 (IMP-5)) to 
      a high-protein (HP) meal leads to early satiety and a difference in energy intake 
      at a second course was investigated. Ten men and twelve women consumed, in random 
      order, a first-course meal consisting of: (1) water (control); (2) a HP meal with 
      0.6% MSG and 0.25% IMP-5; (3) a HP meal with no additives; (4) a HP meal with MSG 
      only; (5) a sham-fed meal 2 (oral-stimulation). Appetite perceptions, plasma 
      concentrations of glucagon-like peptide 1 (GLP-1), glucose and insulin, and 
      energy intake at a buffet (i.e. a second course) were measured before and after 
      each condition. Changes in appetite, and in GLP-1, glucose and insulin, were 
      similar for the three fed HP conditions and all were greater (post hoc all P < 
      0.01) than the control and sham conditions. Energy intake was not different 
      following the HP+MSG+IMP (1.86 (SEM 0.3) MJ) as compared with the HP+MSG-only 
      (2.24 (SEM 0.28) MJ) condition (P = 0.08), or for the HP+MSG+IMP compared with 
      the HP no-additives condition (1.60 (SEM 0.29) MJ) (P = 0.21). Following the 
      HP+MSG-only condition, 0.64 (SEM 0.20) MJ more energy was consumed compared with 
      the HP no-additives condition (P = 0.005). We conclude that the addition of MSG 
      to a HP meal does not influence perceptions of satiety and it may increase energy 
      intake at a second course. Cephalic responses after the sham condition were of 
      similar magnitude to the control and therefore just tasting food is not enough to 
      influence appetite and energy intake.
FAU - Luscombe-Marsh, Natalie D
AU  - Luscombe-Marsh ND
AD  - Department of Human Biology, Maastricht University, PO Box 616, 6200 MD, 
      Maastricht, The Netherlands. natalie.luscombe-marsh@hotmail.com
FAU - Smeets, Astrid J P G
AU  - Smeets AJ
FAU - Westerterp-Plantenga, Margriet S
AU  - Westerterp-Plantenga MS
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
DEP - 20090309
PL  - England
TA  - Br J Nutr
JT  - The British journal of nutrition
JID - 0372547
RN  - 0 (Blood Glucose)
RN  - 0 (Dietary Carbohydrates)
RN  - 0 (Dietary Fats)
RN  - 0 (Dietary Proteins)
RN  - 0 (Food Additives)
RN  - 0 (Insulin)
RN  - 131-99-7 (Inosine Monophosphate)
RN  - 89750-14-1 (Glucagon-Like Peptide 1)
RN  - W81N5U6R6U (Sodium Glutamate)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Blood Glucose/metabolism
MH  - Cross-Over Studies
MH  - Dietary Carbohydrates/administration & dosage
MH  - Dietary Fats/administration & dosage
MH  - Dietary Proteins/*administration & dosage
MH  - Energy Intake/*drug effects
MH  - Female
MH  - Food Additives/*pharmacology
MH  - Glucagon-Like Peptide 1/blood
MH  - Humans
MH  - Inosine Monophosphate/*pharmacology
MH  - Insulin/blood
MH  - Male
MH  - Middle Aged
MH  - Satiation/*drug effects
MH  - Single-Blind Method
MH  - Sodium Glutamate/*pharmacology
MH  - Young Adult
EDAT- 2009/03/10 09:00
MHDA- 2009/11/17 06:00
CRDT- 2009/03/10 09:00
PHST- 2009/03/10 09:00 [entrez]
PHST- 2009/03/10 09:00 [pubmed]
PHST- 2009/11/17 06:00 [medline]
AID - S0007114509297212 [pii]
AID - 10.1017/S0007114509297212 [doi]
PST - ppublish
SO  - Br J Nutr. 2009 Sep;102(6):929-37. doi: 10.1017/S0007114509297212. Epub 2009 Mar 
      9.