PMID- 19269101
OWN - NLM
STAT- MEDLINE
DCOM- 20100315
LR  - 20090410
IS  - 1879-1409 (Electronic)
IS  - 0305-4179 (Linking)
VI  - 35
IP  - 4
DP  - 2009 Jun
TI  - Circulating dendritic cells following burn.
PG  - 513-8
LID - 10.1016/j.burns.2008.05.027 [doi]
AB  - Burns are associated with immune suppression and subsequent development of 
      sepsis. Dendritic cells (DCs) are potent antigen-presenting cells that serve as a 
      critical link between the innate and acquired immune systems, and are essential 
      in coordinating the host response to pathogens. Using multicolour flow cytometry, 
      the percentages of LIN(-) DR(+) CD11c(+) myeloid (mDC) and LIN(-) DR(+) CD123(+) 
      plasmacytoid (pDC) subsets were determined in peripheral blood from 32 people (15 
      septic and 5 non-septic burn victims and 12 age- and gender-matched healthy 
      controls, up to 20 days from injury). Analysis revealed significant reductions in 
      circulating mDCs and pDCs in survivor as well as non-survivor septic cases 
      compared with non-septic cases and controls (p<0.001). These findings suggest 
      that deficiencies in mDCs and pDC subsets are related to sepsis following severe 
      burn, and may contribute to immunosuppression among burn victims.
FAU - D'Arpa, N
AU  - D'Arpa N
AD  - Plastic Surgery and Burns Therapy Operating Unit, ARNAS, Civic Hospital, Piazza 
      Leotta 4, 90127 Palermo, Italy. lab.biotecno@ospedalecivicopa.org
FAU - Accardo-Palumbo, A
AU  - Accardo-Palumbo A
FAU - Amato, G
AU  - Amato G
FAU - D'Amelio, L
AU  - D'Amelio L
FAU - Pileri, D
AU  - Pileri D
FAU - Cataldo, V
AU  - Cataldo V
FAU - Mogavero, R
AU  - Mogavero R
FAU - Lombardo, C
AU  - Lombardo C
FAU - Napoli, B
AU  - Napoli B
FAU - Conte, F
AU  - Conte F
LA  - eng
PT  - Journal Article
DEP - 20090306
PL  - Netherlands
TA  - Burns
JT  - Burns : journal of the International Society for Burn Injuries
JID - 8913178
SB  - IM
MH  - Adult
MH  - Age Factors
MH  - Antigen-Presenting Cells/*cytology/immunology
MH  - Burns/*immunology/mortality
MH  - Case-Control Studies
MH  - Cell Separation
MH  - Dendritic Cells/cytology/*immunology
MH  - Female
MH  - Flow Cytometry
MH  - Humans
MH  - Immunity, Cellular
MH  - Male
MH  - Middle Aged
MH  - Myeloid Cells/cytology/*immunology
MH  - Sepsis/*immunology/mortality
EDAT- 2009/03/10 09:00
MHDA- 2010/03/17 06:00
CRDT- 2009/03/10 09:00
PHST- 2008/01/08 00:00 [received]
PHST- 2008/05/29 00:00 [accepted]
PHST- 2009/03/10 09:00 [entrez]
PHST- 2009/03/10 09:00 [pubmed]
PHST- 2010/03/17 06:00 [medline]
AID - S0305-4179(08)00190-3 [pii]
AID - 10.1016/j.burns.2008.05.027 [doi]
PST - ppublish
SO  - Burns. 2009 Jun;35(4):513-8. doi: 10.1016/j.burns.2008.05.027. Epub 2009 Mar 6.