PMID- 19270394
OWN - NLM
STAT- MEDLINE
DCOM- 20090608
LR  - 20190911
IS  - 1347-6947 (Electronic)
IS  - 0916-8451 (Linking)
VI  - 73
IP  - 3
DP  - 2009 Mar 23
TI  - Fermented barley extract suppresses the development of atopic dermatitis-like 
      skin lesions in NC/Nga mice, probably by inhibiting inflammatory cytokines.
PG  - 489-93
AB  - We have found that fermented barley extract (FBE), prepared from barley shochu 
      residue, alleviates allergic rhinitis in OVA-sensitized mice. In this study, we 
      examined to determine whether FBE suppresses the development of atopic dermatitis 
      (AD)-like skin lesions in NC/Nga mice. The development of AD-like skin lesions in 
      a 5% FBE containing diet group was significantly inhibited, and scratching 
      behavior, one of aggravating factors, was also suppressed. Neither serum 
      immunoglobulin E (IgE) levels nor interleukin (IL)-4 production by spleen cells 
      in the 5% FBE diet group was found to be significantly reduced. On the other 
      hand, interferon-gamma (IFN-gamma) and IL-17 production by spleen cells in the 5% 
      FBE diet group was significantly reduced. Hence it was assumed that FBE 
      alleviates AD-like skin lesions in NC/Nga mice, probably by modulating the 
      cytokine production involved in chronic inflammation, such as IFN-gamma or IL-17.
FAU - Iguchi, Takafumi
AU  - Iguchi T
AD  - YAEGAKI Bio-Industry, Inc., Himeji, Hyogo, Japan. iguch-tk@yaegaki.co.jp
FAU - Kawata, Ayumi
AU  - Kawata A
FAU - Watanabe, Toshiro
AU  - Watanabe T
FAU - Mazumder, Tapan Kumar
AU  - Mazumder TK
FAU - Tanabe, Soichi
AU  - Tanabe S
LA  - eng
PT  - Journal Article
DEP - 20090307
PL  - England
TA  - Biosci Biotechnol Biochem
JT  - Bioscience, biotechnology, and biochemistry
JID - 9205717
RN  - 0 (Cytokines)
RN  - 0 (Haptens)
RN  - 0 (Plant Extracts)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Animals
MH  - Behavior, Animal/drug effects
MH  - Body Weight/drug effects
MH  - Cytokines/*antagonists & inhibitors/metabolism
MH  - Dermatitis, Atopic/pathology/*prevention & control
MH  - Female
MH  - *Fermentation
MH  - Haptens/adverse effects
MH  - Hordeum/*chemistry/*metabolism
MH  - Immunoglobulin E/blood
MH  - Inflammation/metabolism/prevention & control
MH  - Mice
MH  - Plant Extracts/*pharmacology
MH  - Skin/*drug effects/metabolism/pathology
MH  - Spleen/drug effects/metabolism
EDAT- 2009/03/10 09:00
MHDA- 2009/06/09 09:00
CRDT- 2009/03/10 09:00
PHST- 2009/03/10 09:00 [entrez]
PHST- 2009/03/10 09:00 [pubmed]
PHST- 2009/06/09 09:00 [medline]
AID - JST.JSTAGE/bbb/80436 [pii]
AID - 10.1271/bbb.80436 [doi]
PST - ppublish
SO  - Biosci Biotechnol Biochem. 2009 Mar 23;73(3):489-93. doi: 10.1271/bbb.80436. Epub 
      2009 Mar 7.