PMID- 19271313
OWN - NLM
STAT- MEDLINE
DCOM- 20090615
LR  - 20240426
IS  - 1878-5891 (Electronic)
IS  - 0378-5955 (Print)
IS  - 0378-5955 (Linking)
VI  - 249
IP  - 1-2
DP  - 2009 Mar
TI  - Interactions of hearing loss and diabetes mellitus in the middle age CBA/CaJ 
      mouse model of presbycusis.
PG  - 44-53
LID - 10.1016/j.heares.2009.01.007 [doi]
AB  - Recently, we characterized the more severe nature of hearing loss in aged Type 2 
      diabetic human subjects [Frisina, S.T., Mapes, F., Kim, S., Frisina, D.R., 
      Frisina, R.D., 2006. Characterization of hearing loss in aged type II diabetics. 
      Hear. Res. 211, 103-113]. The current study prospectively assessed hearing 
      abilities in middle age CBA/CaJ mice with Type 1 diabetes mellitus (T1DM) (STZ 
      injection) or Type 2 diabetes mellitus (T2DM) (high fat diet), for a period of 6 
      months. Blood glucose, body weight and auditory tests (Auditory Brainstem 
      Response-ABR, Distortion Product Otoacoustic Emissions-DPOAE) were evaluated at 
      baseline and every 2 months. Tone and broad-band noise-burst responses in the 
      inferior colliculus were obtained at 6 months. Body weights of controls did not 
      change over 6 months (approximately 32 g), but there was a significant 
      (approximately 5 g) decline in the T1DM, while T2DM exhibited approximately 10 g 
      weight gain. Blood glucose levels significantly increased: 3-fold for T1DM, 
      1.3-fold for T2DM; with no significant changes in controls. ABR threshold 
      elevations were found for both types of diabetes, but were most pronounced in the 
      T2DM, starting as early as 2 months after induction of diabetes. A decline of 
      mean DPOAE amplitudes was observed in both diabetic groups at high frequencies, 
      and for the T2DM at low frequencies. In contrast to ABR thresholds, tone and 
      noise thresholds in the inferior colliculus were lower for both diabetic groups. 
      Induction of diabetes in middle-aged CBA/CaJ mice promotes amplification of 
      age-related peripheral hearing loss which makes it a suitable model for studying 
      the interaction of age-related hearing loss and diabetes. On the other hand, 
      initial results of effects from very high blood glucose level (T1DM) on the 
      auditory midbrain showed disruption of central inhibition, increased response 
      synchrony or enhanced excitation in the inferior colliculus.
FAU - Vasilyeva, Olga N
AU  - Vasilyeva ON
AD  - Otolaryngology Department, University of Rochester Medical School & Dentistry, 
      601 Elmwood Ave., Rochester, NY 14642-8629, USA.
FAU - Frisina, Susan T
AU  - Frisina ST
FAU - Zhu, Xiaoxia
AU  - Zhu X
FAU - Walton, Joseph P
AU  - Walton JP
FAU - Frisina, Robert D
AU  - Frisina RD
LA  - eng
GR  - P01 AG009524-10/AG/NIA NIH HHS/United States
GR  - P01 AG009524-12/AG/NIA NIH HHS/United States
GR  - P01 AG009524-150005/AG/NIA NIH HHS/United States
GR  - P01 AG009524-140005/AG/NIA NIH HHS/United States
GR  - P01 AG009524-14/AG/NIA NIH HHS/United States
GR  - P01 AG009524-13/AG/NIA NIH HHS/United States
GR  - P01 AG009524-11A10005/AG/NIA NIH HHS/United States
GR  - P01 AG009524-130005/AG/NIA NIH HHS/United States
GR  - P01 AG009524-120005/AG/NIA NIH HHS/United States
GR  - P01 AG009524-11A1/AG/NIA NIH HHS/United States
GR  - P01 AG09524/AG/NIA NIH HHS/United States
GR  - P01 AG009524-15/AG/NIA NIH HHS/United States
GR  - P30 DC05409/DC/NIDCD NIH HHS/United States
GR  - P01 AG009524-100005/AG/NIA NIH HHS/United States
GR  - P01 AG009524/AG/NIA NIH HHS/United States
GR  - P30 DC005409/DC/NIDCD NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PL  - Netherlands
TA  - Hear Res
JT  - Hearing research
JID - 7900445
RN  - 0 (Blood Glucose)
SB  - IM
MH  - Aging/physiology
MH  - Animals
MH  - Auditory Threshold
MH  - Blood Glucose/metabolism
MH  - Diabetes Mellitus, Experimental/*complications/physiopathology
MH  - Diabetes Mellitus, Type 2/complications
MH  - Disease Models, Animal
MH  - Evoked Potentials, Auditory
MH  - Evoked Potentials, Auditory, Brain Stem
MH  - Humans
MH  - Inferior Colliculi/physiopathology
MH  - Male
MH  - Mice
MH  - Mice, Inbred CBA
MH  - Otoacoustic Emissions, Spontaneous
MH  - Presbycusis/*complications/physiopathology
PMC - PMC2891295
MID - NIHMS93001
EDAT- 2009/03/10 09:00
MHDA- 2009/06/16 09:00
PMCR- 2010/07/01
CRDT- 2009/03/10 09:00
PHST- 2009/03/10 09:00 [entrez]
PHST- 2009/03/10 09:00 [pubmed]
PHST- 2009/06/16 09:00 [medline]
PHST- 2010/07/01 00:00 [pmc-release]
AID - S0378-5955(09)00010-0 [pii]
AID - 10.1016/j.heares.2009.01.007 [doi]
PST - ppublish
SO  - Hear Res. 2009 Mar;249(1-2):44-53. doi: 10.1016/j.heares.2009.01.007.