PMID- 19272198
OWN - NLM
STAT- MEDLINE
DCOM- 20090921
LR  - 20090903
IS  - 1469-4409 (Electronic)
IS  - 0950-2688 (Linking)
VI  - 137
IP  - 10
DP  - 2009 Oct
TI  - Population-based contact investigation of a cluster of tuberculosis cases in a 
      small village.
PG  - 1426-35
LID - 10.1017/S0950268809002246 [doi]
AB  - A cluster of five cases of tuberculosis (TB) in persons aged 19-23 years who were 
      not close contacts was detected in a small village in Spain in 2006. All culture 
      isolates had the same chromosomal-DNA restriction pattern. Contact investigations 
      of family members, friends, workmates and schoolmates were complemented with 
      tuberculin screening offered to the resident population born between 1976 and 
      1995. Expanded contact tracing detected two new cases of TB, 27 tuberculin 
      conversions and an excess of latent tuberculosis infections (LTI) in persons born 
      between 1978 and 1990. The contacts of two cases had a significantly elevated 
      prevalence of LTI. Two secondary cases of TB, 33.3% of those diagnosed with LTI 
      and 47.8% of the converters were unaware of any contact with the TB cases, but 
      had frequented some of the same bars. This study suggests that a considerable 
      percentage of the episodes of TB transmission in young people may escape 
      detection in conventional contact studies.
FAU - Castilla, J
AU  - Castilla J
AD  - Insituto de Salud Publica de Navarra, Pamplona, Spain. jcastilc@navarra.es
FAU - Palmera, R
AU  - Palmera R
FAU - Navascues, A
AU  - Navascues A
FAU - Abeti, M
AU  - Abeti M
FAU - Guillermo, A
AU  - Guillermo A
FAU - Irisarri, F
AU  - Irisarri F
FAU - Jimenez, M S
AU  - Jimenez MS
FAU - Garcia Cenoz, M
AU  - Garcia Cenoz M
FAU - Barricarte, A
AU  - Barricarte A
LA  - eng
PT  - Case Reports
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20090310
PL  - England
TA  - Epidemiol Infect
JT  - Epidemiology and infection
JID - 8703737
RN  - 0 (DNA, Bacterial)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Bacterial Typing Techniques/methods
MH  - Cluster Analysis
MH  - *Contact Tracing
MH  - DNA Fingerprinting/methods
MH  - DNA, Bacterial/genetics
MH  - Female
MH  - Humans
MH  - Male
MH  - Mycobacterium tuberculosis/classification/genetics/isolation & purification
MH  - Polymorphism, Restriction Fragment Length
MH  - Rural Population
MH  - Spain/epidemiology
MH  - Tuberculin Test
MH  - Tuberculosis/*epidemiology/microbiology/*transmission
MH  - Young Adult
EDAT- 2009/03/11 09:00
MHDA- 2009/09/22 06:00
CRDT- 2009/03/11 09:00
PHST- 2009/03/11 09:00 [entrez]
PHST- 2009/03/11 09:00 [pubmed]
PHST- 2009/09/22 06:00 [medline]
AID - S0950268809002246 [pii]
AID - 10.1017/S0950268809002246 [doi]
PST - ppublish
SO  - Epidemiol Infect. 2009 Oct;137(10):1426-35. doi: 10.1017/S0950268809002246. Epub 
      2009 Mar 10.