PMID- 19272325
OWN - NLM
STAT- MEDLINE
DCOM- 20090925
LR  - 20221207
IS  - 1879-1166 (Electronic)
IS  - 0198-8859 (Linking)
VI  - 70
IP  - 4
DP  - 2009 Apr
TI  - Association between human leukocyte antigen class II alleles and human 
      papillomavirus-mediated cervical cancer in Indian women.
PG  - 222-9
LID - 10.1016/j.humimm.2009.01.003 [doi]
AB  - We investigated the association of human leukocyte antigen (HLA) II (DRB1 and 
      DQB1) alleles with susceptibility to human papillomavirus (HPV)-associated 
      cervical precancer and cancer cases in a hospital-based case-control study in a 
      northern Indian population. A total of 202 subjects, including 100 patients 
      comprising 31 cervical precancer (cervical intraepithelial neoplasia [CIN] 2/3) 
      and 69 invasive cervical cancer cases, and 102 healthy controls participated in 
      the study. Both patients and controls were screened for HPV infection using a 
      polymerase chain reaction (PCR-based approach. Low-resolution PCR-sequence 
      specific priming (PCR-SSP) was used to genotype HLA II (DRB1 and DQB1). Our 
      results demonstrate that the DRB1*15 allele/DRB1*15-DQB1*06 haplotype may have a 
      predisposition for HPV infection (p(c) < 0.05) or cervical cancer/precancer (p(c) 
      < 0.05) development, whereas the DRB1*04 allele/DRB1*04-DQB1*03 haplotype might 
      exhibit susceptibility to cervical precancerous lesions (p(c) < 0.05). The 
      DRB1*13 allele/DRB1*13-DQB1*06 haplotype was strongly protective against risk to 
      HPV infection (p(c) < 0.002) as well as cervical cancer (p(c) 0.01). Therefore, 
      we have demonstrated that HLA DR-DQ polymorphisms are involved in genetic 
      susceptibility to cervical cancer or HPV infection in a northern Indian 
      population.
FAU - Kohaar, Indu
AU  - Kohaar I
AD  - Division of Molecular Genetics and Biochemistry, Institute of Cytology and 
      Preventive Oncology (ICMR), I-7, Sector 39, Noida 201 301, India.
FAU - Hussain, Showket
AU  - Hussain S
FAU - Thakur, Nisha
AU  - Thakur N
FAU - Tiwari, Pratibha
AU  - Tiwari P
FAU - Nasare, Vilas
AU  - Nasare V
FAU - Batra, Swaraj
AU  - Batra S
FAU - Singh, Veena
AU  - Singh V
FAU - Bhambani, Suresh
AU  - Bhambani S
FAU - Das, Bhudev C
AU  - Das BC
FAU - Sarkar, Debi P
AU  - Sarkar DP
FAU - Bharadwaj, Mausumi
AU  - Bharadwaj M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20090118
PL  - United States
TA  - Hum Immunol
JT  - Human immunology
JID - 8010936
RN  - 0 (HLA-DQ Antigens)
RN  - 0 (HLA-DQ beta-Chains)
RN  - 0 (HLA-DQB1 antigen)
RN  - 0 (HLA-DR Antigens)
RN  - 0 (HLA-DRB1 Chains)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Alleles
MH  - Case-Control Studies
MH  - Chi-Square Distribution
MH  - Female
MH  - Gene Frequency
MH  - Genetic Predisposition to Disease
MH  - HLA-DQ Antigens/*genetics
MH  - HLA-DQ beta-Chains
MH  - HLA-DR Antigens/*genetics
MH  - HLA-DRB1 Chains
MH  - Haplotypes
MH  - Humans
MH  - India
MH  - Linkage Disequilibrium
MH  - Middle Aged
MH  - Papillomavirus Infections/complications/*genetics
MH  - Polymerase Chain Reaction
MH  - Polymorphism, Genetic
MH  - Polymorphism, Single-Stranded Conformational
MH  - Uterine Cervical Neoplasms/complications/*genetics
MH  - Young Adult
MH  - Uterine Cervical Dysplasia/complications/*genetics
EDAT- 2009/03/11 09:00
MHDA- 2009/09/26 06:00
CRDT- 2009/03/11 09:00
PHST- 2008/08/18 00:00 [received]
PHST- 2008/11/14 00:00 [revised]
PHST- 2009/01/10 00:00 [accepted]
PHST- 2009/03/11 09:00 [entrez]
PHST- 2009/03/11 09:00 [pubmed]
PHST- 2009/09/26 06:00 [medline]
AID - S0198-8859(09)00008-1 [pii]
AID - 10.1016/j.humimm.2009.01.003 [doi]
PST - ppublish
SO  - Hum Immunol. 2009 Apr;70(4):222-9. doi: 10.1016/j.humimm.2009.01.003. Epub 2009 
      Jan 18.