PMID- 19273437
OWN - NLM
STAT- MEDLINE
DCOM- 20090515
LR  - 20190923
IS  - 0253-9772 (Print)
IS  - 0253-9772 (Linking)
VI  - 31
IP  - 3
DP  - 2009 Mar
TI  - [Aneuploid analysis of chromosomes 3, 8, 10, 20 and Y in esophageal squamous cell 
      carcinoma].
PG  - 255-60
AB  - Although the diagnostic and therapeutic modalities of esophageal squamous cell 
      carcinoma (ESCC) have been improved considerably, the five-year survival rate is 
      still not satisfied. To detect the numberial aberrations of the chromosomes in 
      ESCC, fluorescence in situ hybridization (FISH) was performed on interphase 
      nuclei prepared from 220 esophageal carcinoma tissues with specific centromeric 
      probes for chromosomes 3, 8, 10, 20 and Y. The main aberrations of the 
      euchromosomes was chromosome gain, including trisome, tetrasome, and polysome. 
      The gain rates of the four euchromosome were 84.9%, 77.5%, 63.7% and 83.2%, and 
      the frequencies of polysome for each euchromosome were 24.6%, 34.9%, 23.4% and 
      31.7%, respectively. Loss of chromosome Y was observed in 61.2% of male patients. 
      The combination of the four chromosome probes 3, 8, 10 and 20 detected 74.5% of 
      ESCC and the combination of 3, 8, 20 and Y detected 85.0%. These results 
      indicated that both sets of the four centromeric probe combinations provide 
      candidate biomarkers for the diagnosis of esophageal squamous cell carcinoma.
FAU - Kang, Wei
AU  - Kang W
AD  - Department of Histology and Embryology, Anhui Medical University, Hefei, China. 
      kangwei.222@163.com
FAU - Yao, Han-Qing
AU  - Yao HQ
FAU - Fang, Li-Li
AU  - Fang LL
FAU - Cai, Yan
AU  - Cai Y
FAU - Han, Ya-Ling
AU  - Han YL
FAU - Xu, Xin
AU  - Xu X
FAU - Zhang, Yu
AU  - Zhang Y
FAU - Jia, Xue-Mei
AU  - Jia XM
FAU - Wang, Ming-Rong
AU  - Wang MR
LA  - chi
PT  - English Abstract
PT  - Journal Article
PL  - China
TA  - Yi Chuan
JT  - Yi chuan = Hereditas
JID - 9436478
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - *Aneuploidy
MH  - Carcinoma, Squamous Cell/*genetics
MH  - Chromosomes, Human, Pair 10/*genetics
MH  - Chromosomes, Human, Pair 20/*genetics
MH  - Chromosomes, Human, Pair 3/*genetics
MH  - Chromosomes, Human, Pair 8/*genetics
MH  - Chromosomes, Human, Y/genetics
MH  - Esophageal Neoplasms/*genetics
MH  - Female
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - In Vitro Techniques
MH  - Male
MH  - Middle Aged
EDAT- 2009/03/11 09:00
MHDA- 2009/05/16 09:00
CRDT- 2009/03/11 09:00
PHST- 2009/03/11 09:00 [entrez]
PHST- 2009/03/11 09:00 [pubmed]
PHST- 2009/05/16 09:00 [medline]
AID - 0253-9772(2009)02-255-06 [pii]
AID - 10.3724/sp.j.1005.2009.00255 [doi]
PST - ppublish
SO  - Yi Chuan. 2009 Mar;31(3):255-60. doi: 10.3724/sp.j.1005.2009.00255.