PMID- 19274687
OWN - NLM
STAT- MEDLINE
DCOM- 20110127
LR  - 20131121
IS  - 1099-1573 (Electronic)
IS  - 0951-418X (Linking)
VI  - 23
IP  - 9
DP  - 2009 Sep
TI  - Antidiabetic and antioxidant effects of oleanolic acid from Ligustrum lucidum Ait 
      in alloxan-induced diabetic rats.
PG  - 1257-62
LID - 10.1002/ptr.2603 [doi]
AB  - The present study evaluated the antidiabetic and antioxidant effects of oleanolic 
      acid (OA) from Ligustrum lucidum Ait (LLA) in alloxan-induced diabetic rats. OA 
      in the alloxan-induced diabetic rats showed significant hypoglycemic activity by 
      lowering blood glucose (at doses of 60 and 100 mg/kg for 40 days). The levels of 
      serum total cholesterol (TC), triglycerides (TG) and low-density lipoprotein 
      cholesterol (LDL-c) in the OA-treated diabetic rats were lower, and the 
      high-density lipoprotein cholesterol (HDL-c) level was higher than in the control 
      diabetic rats. A significant reduction in the serum aspartate aminotransferase 
      (AST), alanine aminotransferase (ALT) and alkaline phosphatase (ALP) levels of 
      diabetic rats following OA treatment was also observed. Furthermore, OA treatment 
      decreased the malondialdehyde (MDA) level, but increased superoxide dismutase 
      (SOD) and glutathione peroxidase (GSH-px) activities of the liver and kidney in 
      diabetic rats. These results indicate that OA could protect the liver function 
      avoiding alloxan-induced damage; OA had hypoglycemic, hypolipidemic and 
      antioxidant efficacy in the diabetic rats. The antioxidant ability of OA might be 
      one of the mechanisms of its hypoglycemic and hypolipidemic effects.
FAU - Gao, Dawei
AU  - Gao D
AD  - Department of Biological Engineering, College of Environmental and Chemical 
      Engineering, Yanshan University, No.438 Hebei Street, Qinhuangdao 066004, China.
FAU - Li, Qingwang
AU  - Li Q
FAU - Li, Ying
AU  - Li Y
FAU - Liu, Zhihua
AU  - Liu Z
FAU - Fan, Yusheng
AU  - Fan Y
FAU - Liu, Zhiwei
AU  - Liu Z
FAU - Zhao, Hongwei
AU  - Zhao H
FAU - Li, Jian
AU  - Li J
FAU - Han, Zengsheng
AU  - Han Z
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Phytother Res
JT  - Phytotherapy research : PTR
JID - 8904486
RN  - 0 (Antioxidants)
RN  - 0 (Blood Glucose)
RN  - 0 (Hypoglycemic Agents)
RN  - 0 (Hypolipidemic Agents)
RN  - 0 (Triglycerides)
RN  - 6SMK8R7TGJ (Oleanolic Acid)
RN  - 6SW5YHA5NG (Alloxan)
RN  - 97C5T2UQ7J (Cholesterol)
SB  - IM
MH  - Alloxan
MH  - Animals
MH  - Antioxidants/*therapeutic use
MH  - Blood Glucose/drug effects
MH  - Cholesterol/blood
MH  - Diabetes Mellitus, Experimental/*drug therapy
MH  - Hypoglycemic Agents/*therapeutic use
MH  - Hypolipidemic Agents/therapeutic use
MH  - Ligustrum/*chemistry
MH  - Oleanolic Acid/*therapeutic use
MH  - Phytotherapy
MH  - Rats
MH  - Rats, Wistar
MH  - Triglycerides/blood
EDAT- 2009/03/11 09:00
MHDA- 2011/01/29 06:00
CRDT- 2009/03/11 09:00
PHST- 2009/03/11 09:00 [entrez]
PHST- 2009/03/11 09:00 [pubmed]
PHST- 2011/01/29 06:00 [medline]
AID - 10.1002/ptr.2603 [doi]
PST - ppublish
SO  - Phytother Res. 2009 Sep;23(9):1257-62. doi: 10.1002/ptr.2603.