PMID- 19274922
OWN - NLM
STAT- MEDLINE
DCOM- 20090505
LR  - 20181201
IS  - 1018-9068 (Print)
IS  - 1018-9068 (Linking)
VI  - 19
IP  - 1
DP  - 2009
TI  - Does treatment with proton pump inhibitors for gastroesophageal reflux disease 
      (GERD) improve asthma symptoms in children with asthma and GERD? A systematic 
      review.
PG  - 1-5
AB  - OBJECTIVE: To evaluate pediatric studies of the effect on asthma symptoms of 
      treatment with proton pump inhibitors (PPI) used to treat gastroesophageal reflux 
      disease (GERD). METHODS: We entered the MeSH terms "gastroesophageal reflux AND 
      asthma AND children" in the PubMed tool Clinical Queries, selecting "therapy" and 
      "broad, sensitive search." The search ended on April 14, 2008. We included only 
      clinical trials performed in pediatric patients. RESULTS: Four studies were 
      considered to be relevant, although only 1 was a randomized, double-blind, 
      placebo-controlled trial. The 3 nonrandomized trials showed that PPIs benefited 
      patients with asthma. The randomized, double-blind, placebo-controlled trial 
      found that omeprazole did not improve asthma symptoms. An improved (although not 
      statistically significant) score was observed in the quality of life 
      questionnaire in children with a reflux index greater than 10% and in those with 
      more severe asthma treated with omeprazole compared with the placebo group. 
      CONCLUSIONS: Scant data in these studies mean that we cannot make solid 
      recommendations. However, in specific cases, we think that treatment of asthma 
      symptoms with a PPI is valid as long as at least 2 conditions are satisfied: 
      asthma must not respond to standard treatment, and 1 instrumental parameter of 
      GERD severity must be satisfied, that is, a reflux index greater than or equal to 
      10 must be present.
FAU - Sopo, S Miceli
AU  - Sopo SM
AD  - Department of Pediatrics, Catholic University of Rome, Rome, Italy 
      smicelisopo@rm.unicatt.it
FAU - Radzik, D
AU  - Radzik D
FAU - Calvani, M
AU  - Calvani M
LA  - eng
PT  - Journal Article
PT  - Review
PT  - Systematic Review
PL  - Spain
TA  - J Investig Allergol Clin Immunol
JT  - Journal of investigational allergology & clinical immunology
JID - 9107858
RN  - 0 (Proton Pump Inhibitors)
RN  - KG60484QX9 (Omeprazole)
SB  - IM
MH  - Asthma/*complications/*drug therapy
MH  - Child
MH  - Gastroesophageal Reflux/*complications/*drug therapy
MH  - Humans
MH  - Omeprazole/*therapeutic use
MH  - Proton Pump Inhibitors/*therapeutic use
MH  - Randomized Controlled Trials as Topic
RF  - 11
EDAT- 2009/03/12 09:00
MHDA- 2009/05/06 09:00
CRDT- 2009/03/12 09:00
PHST- 2009/03/12 09:00 [entrez]
PHST- 2009/03/12 09:00 [pubmed]
PHST- 2009/05/06 09:00 [medline]
PST - ppublish
SO  - J Investig Allergol Clin Immunol. 2009;19(1):1-5.