PMID- 19276793
OWN - NLM
STAT- MEDLINE
DCOM- 20100330
LR  - 20221207
IS  - 1473-5571 (Electronic)
IS  - 0269-9370 (Print)
IS  - 0269-9370 (Linking)
VI  - 23
IP  - 6
DP  - 2009 Mar 27
TI  - Host genetics and HIV-1 viral load set-point in African-Americans.
PG  - 673-7
LID - 10.1097/QAD.0b013e328325d414 [doi]
AB  - OBJECTIVE: In a recent genome-wide association study of HIV-1-infected 
      individuals in the Euro-CHAVI cohort, viral load set-point was strongly 
      associated with genotypes defined by two single nucleotide polymorphisms (SNPs) 
      (rs9264942 and rs2395029) within the human major histocompatibility complex (MHC) 
      region on chromosome 6. We attempted to confirm this finding in African-Americans 
      and to address whether these SNPs are in linkage disequilibrium with human 
      leukocyte antigen (HLA) class I alleles that mediate innate and adaptive 
      immunity. DESIGN: Our analyses relied on 121 African-American adolescents with 
      chronic HIV-1 infection and quarterly immunological and virological outcome 
      measures in the absence of therapy. METHODS: PCR-based techniques were used to 
      genotype two SNPs along with HLA class I alleles. Their associations with HIV-1 
      viral load set-point and longitudinal CD4+ and CD8+CD38+ T cell counts were 
      tested in univariate and multivariable models. RESULTS: The CC genotype at 
      rs9264942 was associated with reduced viral load, but not with immunological 
      outcomes or category of disease control. Consistent associations of favorable 
      virologic outcomes were observed with B*57 (mostly B*5703) but not with 
      rs2395029G allele at the HCP5 locus, which is in absolute linkage disequilibrium 
      with B*5701 (in individuals of European descent), and not B*5703. CONCLUSION: 
      Although rs9264942 and B*57 (but not rs2395029G) are clearly associated with 
      control of viral load set-point among African-Americans, fine-mapping of MHC SNPs 
      in populations of African and European descent should help reveal the causative 
      variants and the underlying functional mechanisms.
FAU - Shrestha, Sadeep
AU  - Shrestha S
AD  - Department of Epidemiology, School of Public Health, University of Alabama at 
      Birmingham, Birmingham, Alabama 35294-0022, USA. sshresth@uab.edu
FAU - Aissani, Brahim
AU  - Aissani B
FAU - Song, Wei
AU  - Song W
FAU - Wilson, Craig M
AU  - Wilson CM
FAU - Kaslow, Richard A
AU  - Kaslow RA
FAU - Tang, Jianming
AU  - Tang J
LA  - eng
GR  - P30 AI027767/AI/NIAID NIH HHS/United States
GR  - R01 AI051173/AI/NIAID NIH HHS/United States
GR  - R01 AI041951/AI/NIAID NIH HHS/United States
GR  - U01 HD032830-07/HD/NICHD NIH HHS/United States
GR  - R01-AI41951/AI/NIAID NIH HHS/United States
GR  - U01 HD040533/HD/NICHD NIH HHS/United States
GR  - P30 AI027767-20/AI/NIAID NIH HHS/United States
GR  - U01-HD32830/HD/NICHD NIH HHS/United States
GR  - R01 AI051173-04/AI/NIAID NIH HHS/United States
GR  - 5P30 AI27767-20/AI/NIAID NIH HHS/United States
GR  - R01-AI51173/AI/NIAID NIH HHS/United States
GR  - R01 AI041951-08/AI/NIAID NIH HHS/United States
PT  - Journal Article
PT  - Multicenter Study
PT  - Research Support, N.I.H., Extramural
PL  - England
TA  - AIDS
JT  - AIDS (London, England)
JID - 8710219
RN  - 0 (Histocompatibility Antigens Class II)
SB  - IM
MH  - Adolescent
MH  - Black or African American/*genetics
MH  - CD4-Positive T-Lymphocytes/immunology
MH  - CD8-Positive T-Lymphocytes/immunology
MH  - Female
MH  - Genetic Predisposition to Disease
MH  - HIV Infections/*genetics/immunology/virology
MH  - HIV-1/*isolation & purification
MH  - Histocompatibility Antigens Class II/genetics
MH  - Histocompatibility Testing
MH  - Humans
MH  - Linkage Disequilibrium
MH  - Male
MH  - Polymerase Chain Reaction/methods
MH  - Polymorphism, Single Nucleotide
MH  - Viral Load
MH  - Young Adult
PMC - PMC2663898
MID - NIHMS89959
EDAT- 2009/03/12 09:00
MHDA- 2010/03/31 06:00
PMCR- 2010/03/27
CRDT- 2009/03/12 09:00
PHST- 2009/03/12 09:00 [entrez]
PHST- 2009/03/12 09:00 [pubmed]
PHST- 2010/03/31 06:00 [medline]
PHST- 2010/03/27 00:00 [pmc-release]
AID - 10.1097/QAD.0b013e328325d414 [doi]
PST - ppublish
SO  - AIDS. 2009 Mar 27;23(6):673-7. doi: 10.1097/QAD.0b013e328325d414.