PMID- 19277634
OWN - NLM
STAT- MEDLINE
DCOM- 20090722
LR  - 20211020
IS  - 1432-1998 (Electronic)
IS  - 0301-0449 (Linking)
VI  - 39
IP  - 6
DP  - 2009 Jun
TI  - Immune reconstitution inflammatory syndrome after initiating highly active 
      antiretroviral therapy in HIV-infected children.
PG  - 569-74
LID - 10.1007/s00247-009-1192-y [doi]
AB  - The outcome of HIV infection has improved since the widespread availability of 
      highly active antiretroviral therapy (HAART). Some patients, however, develop a 
      clinical and radiological deterioration following initiation of HAART due to 
      either the unmasking of occult subclinical infection or an enhanced inflammatory 
      response to a treated infection. This phenomenon is believed to result from the 
      restored ability to mount an immune response and is termed immune reconstitution 
      inflammatory syndrome (IRIS) or immune reconstitution disease. IRIS is widely 
      reported in the literature in adult patients, most commonly associated with 
      mycobacterial infections. There is, however, a paucity of data documenting the 
      radiological findings of IRIS in children. Radiologists need to be aware of this 
      entity. As a diagnosis of exclusion it is essential that the radiological 
      findings be assessed in the context of the clinical presentation. This article 
      reviews the common clinical and radiological manifestations of IRIS in 
      HIV-infected children.
FAU - Kilborn, Tracy
AU  - Kilborn T
AD  - Department of Paediatric Radiology, Red Cross War Memorial Children's Hospital, 
      Rondebosch 7925, Cape Town, South Africa. tracykilborn@gmail.com
FAU - Zampoli, Marco
AU  - Zampoli M
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20090310
PL  - Germany
TA  - Pediatr Radiol
JT  - Pediatric radiology
JID - 0365332
SB  - IM
MH  - Antiretroviral Therapy, Highly Active/*adverse effects
MH  - Child
MH  - HIV Infections/complications/*diagnostic imaging/*drug therapy
MH  - Humans
MH  - Immune Reconstitution Inflammatory Syndrome/*chemically induced/*diagnosis
MH  - Tomography, X-Ray Computed/*methods
RF  - 27
EDAT- 2009/03/12 09:00
MHDA- 2009/07/23 09:00
CRDT- 2009/03/12 09:00
PHST- 2008/11/05 00:00 [received]
PHST- 2009/01/28 00:00 [accepted]
PHST- 2009/01/15 00:00 [revised]
PHST- 2009/03/12 09:00 [entrez]
PHST- 2009/03/12 09:00 [pubmed]
PHST- 2009/07/23 09:00 [medline]
AID - 10.1007/s00247-009-1192-y [doi]
PST - ppublish
SO  - Pediatr Radiol. 2009 Jun;39(6):569-74. doi: 10.1007/s00247-009-1192-y. Epub 2009 
      Mar 10.