PMID- 19280661
OWN - NLM
STAT- MEDLINE
DCOM- 20091214
LR  - 20211020
IS  - 1098-1063 (Electronic)
IS  - 1050-9631 (Print)
IS  - 1050-9631 (Linking)
VI  - 19
IP  - 10
DP  - 2009 Oct
TI  - Voluntary exercise and caloric restriction enhance hippocampal dendritic spine 
      density and BDNF levels in diabetic mice.
PG  - 951-61
LID - 10.1002/hipo.20577 [doi]
AB  - Diabetes may adversely affect cognitive function, but the underlying mechanisms 
      are unknown. To investigate whether manipulations that enhance neurotrophin 
      levels will also restore neuronal structure and function in diabetes, we examined 
      the effects of wheel running and dietary energy restriction on hippocampal neuron 
      morphology and brain-derived neurotrophic factor (BDNF) levels in db/db mice, a 
      model of insulin resistant diabetes. Running wheel activity, caloric restriction, 
      or the combination of the two treatments increased levels of BDNF in the 
      hippocampus of db/db mice. Enhancement of hippocampal BDNF was accompanied by 
      increases in dendritic spine density on the secondary and tertiary dendrites of 
      dentate granule neurons. These studies suggest that diabetes exerts detrimental 
      effects on hippocampal structure, and that this state can be attenuated by 
      increasing energy expenditure and decreasing energy intake.
CI  - Copyright 2008 Wiley-Liss, Inc.
FAU - Stranahan, Alexis M
AU  - Stranahan AM
AD  - Psychology department, Princeton University, Princeton, New Jersey, USA.
FAU - Lee, Kim
AU  - Lee K
FAU - Martin, Bronwen
AU  - Martin B
FAU - Maudsley, Stuart
AU  - Maudsley S
FAU - Golden, Erin
AU  - Golden E
FAU - Cutler, Roy G
AU  - Cutler RG
FAU - Mattson, Mark P
AU  - Mattson MP
LA  - eng
GR  - F31 AG024690-03/AG/NIA NIH HHS/United States
GR  - T32 AG027668/AG/NIA NIH HHS/United States
GR  - ZIA AG000319-02/ImNIH/Intramural NIH HHS/United States
GR  - F31 AG024690-04/AG/NIA NIH HHS/United States
GR  - F31 AG024690/AG/NIA NIH HHS/United States
GR  - F31 AG024690-02/AG/NIA NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PL  - United States
TA  - Hippocampus
JT  - Hippocampus
JID - 9108167
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Receptors, Leptin)
RN  - 0 (leptin receptor, mouse)
SB  - IM
EIN - Hippocampus. 2009 Nov;19(11):1151
MH  - Animals
MH  - Brain-Derived Neurotrophic Factor/*metabolism
MH  - *Caloric Restriction
MH  - Dendritic Spines/*physiology
MH  - Diabetes Mellitus/*physiopathology
MH  - Diet, Reducing
MH  - Disease Models, Animal
MH  - Hippocampus/cytology/*physiopathology
MH  - Male
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Mice, Mutant Strains
MH  - Neurons/cytology/physiology
MH  - Physical Conditioning, Animal/*physiology
MH  - Receptors, Leptin/genetics
MH  - Running/physiology
MH  - Volition
PMC - PMC2755651
MID - NIHMS108454
EDAT- 2009/03/13 09:00
MHDA- 2009/12/16 06:00
PMCR- 2009/12/01
CRDT- 2009/03/13 09:00
PHST- 2009/03/13 09:00 [entrez]
PHST- 2009/03/13 09:00 [pubmed]
PHST- 2009/12/16 06:00 [medline]
PHST- 2009/12/01 00:00 [pmc-release]
AID - 10.1002/hipo.20577 [doi]
PST - ppublish
SO  - Hippocampus. 2009 Oct;19(10):951-61. doi: 10.1002/hipo.20577.