PMID- 19281964 OWN - NLM STAT- MEDLINE DCOM- 20090824 LR - 20091111 IS - 1768-3181 (Electronic) IS - 0003-3928 (Linking) VI - 58 IP - 2 DP - 2009 Apr TI - [Brain-Derived Neurotrophic Factor (BDNF): role of this neurotrophin in cardiovascular physiopathology]. PG - 99-103 LID - 10.1016/j.ancard.2008.11.001 [doi] AB - Neurotrophic-factors research is dominated by neurotrophins (NT): a family of polypeptides which includes molecules such as Nerve Growth Factor (NGF) and the Brain-Derived Neurotrophic Factor (BDNF). They are homodimeric polypeptides. NTs interact with classes of receptors on responsive cells: protein-tyrosine kinase-type receptors (Trk family). It is well established that the levels of NT determine the balance between cell survival and apoptosis during neural development. Recently, it has been shown that BDNF played a role in the etiology of some cardiovascular diseases: induction of angiogenesis in ischemic issues. Plasma BDNF was increased in the circulation in patients with unstable angina. BDNF was expressed in atheromatous intima and adventitia in human coronary artery. Our own studies suggest that BDNF serum levels in patients with acute myocardial infarction or under cardiopulmonary bypass could related to platelet activation, oxidative stress and inflammatory response. Thus, investigations of this new factor: BDNF will help to better understand vascular development and may lead to new therapeutic strategies for some cardiovascular diseases. FAU - Lorgis, L AU - Lorgis L AD - LPPCE, IFR Sante STIC, facultes de medecine et de Pharmacie, 7, boulevard Jeanne-d'Arc, 21033 Dijon, France. FAU - Amoureux, S AU - Amoureux S FAU - Vergely, C AU - Vergely C FAU - Zeller, M AU - Zeller M FAU - Cottin, Y AU - Cottin Y FAU - Rochette, L AU - Rochette L LA - fre PT - English Abstract PT - Journal Article PT - Review TT - Le brain-derived neurotrophic factor (BDNF) : role de cette neurotrophine dans la physiopathologie cardiovasculaire. DEP - 20081203 PL - France TA - Ann Cardiol Angeiol (Paris) JT - Annales de cardiologie et d'angeiologie JID - 0142167 RN - 0 (Brain-Derived Neurotrophic Factor) SB - IM MH - Brain-Derived Neurotrophic Factor/*physiology MH - Heart Diseases/*physiopathology MH - Humans RF - 21 EDAT- 2009/03/14 09:00 MHDA- 2009/08/25 09:00 CRDT- 2009/03/14 09:00 PHST- 2008/10/14 00:00 [received] PHST- 2008/11/04 00:00 [accepted] PHST- 2009/03/14 09:00 [entrez] PHST- 2009/03/14 09:00 [pubmed] PHST- 2009/08/25 09:00 [medline] AID - S0003-3928(08)00226-6 [pii] AID - 10.1016/j.ancard.2008.11.001 [doi] PST - ppublish SO - Ann Cardiol Angeiol (Paris). 2009 Apr;58(2):99-103. doi: 10.1016/j.ancard.2008.11.001. Epub 2008 Dec 3.