PMID- 19283647
OWN - NLM
STAT- MEDLINE
DCOM- 20090626
LR  - 20181201
IS  - 1439-3522 (Electronic)
IS  - 0720-4299 (Linking)
VI  - 77
IP  - 3
DP  - 2009 Mar
TI  - [Empirical evidence for the use of anticonvulsants in personality disorders].
PG  - 133-8
LID - 10.1055/s-0028-1109098 [doi]
AB  - OBJECTIVE: There is a common practice of polypharmacy and an increased use of 
      mood stabilizers in personality disorders (PD). This paper reviews all randomized 
      controlled trials (RCTs) of anticonvulsants to evaluate the evidence base 
      supporting their use in treatment of PD. METHODS: German and English language 
      literature cited in Medline and published between 1970 and 2008 was searched 
      using the following terms: Borderline/personality disorder, anticonvulsant, mood 
      stabilizer, carbamazepine, felbamate, gabapentin, lamotrigine, levetiracetam, 
      oxcarbazepine, phenytoine, pregabalin, tiagabine, topiramate, and valproate. 
      RESULTS: Twelve RCTs were identified which included anticonvulsants in treatment 
      of personality disorders. The anticonvulsants valproate and topiramate appeared 
      to have the most empirical support for having a favorable effect on symptoms of 
      borderline personality disorder. Evidence for the use of other anticonvulsants in 
      patients with PD is sparse. CONCLUSIONS: Valproate and topiramate, probably also 
      lamotrigine, carbamazepine, and oxcarbazepine as well, were useful in treating 
      symptoms of affective dysregulation and impulsive aggression in PD. However, 
      further RCTs of anticonvulsants are greatly needed as clinical use of these 
      agents has risen without sufficient evidence supporting their efficacy and safety 
      in personality disorders.
FAU - Sieberer, M
AU  - Sieberer M
AD  - Zentrum Psychologische Medizin, Klinik fur Psychiatrie, Sozialpsychiatrie und 
      Psychotherapie, Medizinische Hochschule Hannover. Sieberer.Marcel@mh-hannover.de
FAU - Emrich, H M
AU  - Emrich HM
LA  - ger
PT  - Journal Article
PT  - Review
TT  - Evidenz fur den Einsatz von Antikonvulsiva bei Personlichkeitsstorungen.
DEP - 20090312
PL  - Germany
TA  - Fortschr Neurol Psychiatr
JT  - Fortschritte der Neurologie-Psychiatrie
JID - 8103137
RN  - 0 (Amines)
RN  - 0 (Anticonvulsants)
RN  - 0 (Cyclohexanecarboxylic Acids)
RN  - 0 (Triazines)
RN  - 0H73WJJ391 (Topiramate)
RN  - 30237-26-4 (Fructose)
RN  - 33CM23913M (Carbamazepine)
RN  - 55JG375S6M (Pregabalin)
RN  - 56-12-2 (gamma-Aminobutyric Acid)
RN  - 614OI1Z5WI (Valproic Acid)
RN  - 6CW7F3G59X (Gabapentin)
RN  - U3H27498KS (Lamotrigine)
RN  - VZI5B1W380 (Oxcarbazepine)
SB  - IM
MH  - Amines/therapeutic use
MH  - Anticonvulsants/*therapeutic use
MH  - Borderline Personality Disorder/drug therapy/psychology
MH  - Carbamazepine/analogs & derivatives/therapeutic use
MH  - Cyclohexanecarboxylic Acids/therapeutic use
MH  - Fructose/analogs & derivatives/therapeutic use
MH  - Gabapentin
MH  - Humans
MH  - Lamotrigine
MH  - Oxcarbazepine
MH  - Personality Disorders/*drug therapy/psychology
MH  - Pregabalin
MH  - Randomized Controlled Trials as Topic
MH  - Topiramate
MH  - Triazines/therapeutic use
MH  - Valproic Acid/therapeutic use
MH  - gamma-Aminobutyric Acid/analogs & derivatives/therapeutic use
RF  - 31
EDAT- 2009/03/14 09:00
MHDA- 2009/06/27 09:00
CRDT- 2009/03/14 09:00
PHST- 2009/03/14 09:00 [entrez]
PHST- 2009/03/14 09:00 [pubmed]
PHST- 2009/06/27 09:00 [medline]
AID - 10.1055/s-0028-1109098 [doi]
PST - ppublish
SO  - Fortschr Neurol Psychiatr. 2009 Mar;77(3):133-8. doi: 10.1055/s-0028-1109098. 
      Epub 2009 Mar 12.