PMID- 19285498
OWN - NLM
STAT- MEDLINE
DCOM- 20090713
LR  - 20191210
IS  - 1879-0712 (Electronic)
IS  - 0014-2999 (Linking)
VI  - 609
IP  - 1-3
DP  - 2009 May 1
TI  - Gabapentin and pregabalin ameliorate mechanical hypersensitivity after spinal 
      cord injury in mice.
PG  - 65-8
LID - 10.1016/j.ejphar.2009.03.020 [doi]
AB  - The antiepileptic drugs gabapentin and pregabalin exhibit well-established 
      analgesic effects in patients with several neuropathic conditions. In the present 
      study, we examined their effects on mechanical hypersensitivity in mice subjected 
      to weight-drop spinal cord injury. Hindlimb motor function and mechanical 
      hypersensitivity were evaluated using the Basso-Beattie-Bresnahan (BBB) locomotor 
      rating scale and the von Frey test, respectively, for 4 weeks after spinal cord 
      injury. Despite gradual recovery of hindlimb motor function after spinal cord 
      injury, mice exhibited continuous development of mechanical hypersensitivity. 
      Gabapentin (30 and 100 mg/kg) and pregabalin (10 and 30 mg/kg), administered 
      intraperitoneally on the 28th day after spinal cord injury, reduced mechanical 
      hypersensitivity in a dose-dependent manner. These results suggest that 
      gabapentin and pregabalin could be useful therapeutic tools for patients with 
      neuropathic pain after spinal cord injury.
FAU - Tanabe, Mitsuo
AU  - Tanabe M
AD  - Laboratory of CNS Pharmacology, Graduate School of Pharmaceutical Sciences, 
      Nagoya City University, 3-1 Tanabe-dori, Mizuho-ku, Nagoya 467-8603, Japan. 
      mitana@phar.nagoya-cu.ac.jp
FAU - Ono, Koto
AU  - Ono K
FAU - Honda, Motoko
AU  - Honda M
FAU - Ono, Hideki
AU  - Ono H
LA  - eng
PT  - Evaluation Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20090312
PL  - Netherlands
TA  - Eur J Pharmacol
JT  - European journal of pharmacology
JID - 1254354
RN  - 0 (Amines)
RN  - 0 (Analgesics)
RN  - 0 (Cyclohexanecarboxylic Acids)
RN  - 55JG375S6M (Pregabalin)
RN  - 56-12-2 (gamma-Aminobutyric Acid)
RN  - 6CW7F3G59X (Gabapentin)
SB  - IM
MH  - Amines/*pharmacology
MH  - Analgesics/*pharmacology
MH  - Animals
MH  - Cyclohexanecarboxylic Acids/*pharmacology
MH  - Dose-Response Relationship, Drug
MH  - Drug Evaluation, Preclinical
MH  - Female
MH  - Gabapentin
MH  - Hindlimb/physiopathology
MH  - Hypersensitivity/*physiopathology
MH  - Mice
MH  - Mice, Inbred Strains
MH  - Motor Activity/drug effects
MH  - Pregabalin
MH  - Recovery of Function
MH  - Spinal Cord Injuries/*physiopathology
MH  - Time Factors
MH  - gamma-Aminobutyric Acid/*analogs & derivatives/pharmacology
EDAT- 2009/03/17 09:00
MHDA- 2009/07/14 09:00
CRDT- 2009/03/17 09:00
PHST- 2008/12/02 00:00 [received]
PHST- 2009/02/26 00:00 [revised]
PHST- 2009/03/03 00:00 [accepted]
PHST- 2009/03/17 09:00 [entrez]
PHST- 2009/03/17 09:00 [pubmed]
PHST- 2009/07/14 09:00 [medline]
AID - S0014-2999(09)00241-6 [pii]
AID - 10.1016/j.ejphar.2009.03.020 [doi]
PST - ppublish
SO  - Eur J Pharmacol. 2009 May 1;609(1-3):65-8. doi: 10.1016/j.ejphar.2009.03.020. 
      Epub 2009 Mar 12.