PMID- 19285625 OWN - NLM STAT- MEDLINE DCOM- 20090811 LR - 20171116 IS - 1557-3117 (Electronic) IS - 1053-2498 (Linking) VI - 28 IP - 3 DP - 2009 Mar TI - A pediatric case study of treprostinil overdose. PG - 297-8 LID - 10.1016/j.healun.2008.12.006 [doi] AB - This case study reports the effects of a treprostinil accidental overdose in a patient with pulmonary hypertension. Treprostinil is labeled for treatment of pulmonary hypertension with New York Heart Association (NYHA) Class II, III and IV symptoms. It is characterized as a long-acting prostacyclin analog that can be delivered by intravenous or subcutaneous continuous infusions. This pediatric case report describes a massive overdose without significant side effects, thus suggesting a beneficial therapeutic index in pediatric patients. FAU - Walsh, Melinda AU - Walsh M AD - Philadelphia University, Pennsylvania, USA. FAU - Hanna, Brian D AU - Hanna BD LA - eng PT - Case Reports PT - Journal Article PL - United States TA - J Heart Lung Transplant JT - The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation JID - 9102703 RN - 0 (Antihypertensive Agents) RN - DCR9Z582X0 (Epoprostenol) RN - RUM6K67ESG (treprostinil) SB - IM MH - Antihypertensive Agents/*poisoning MH - Child MH - Drug Overdose MH - Epoprostenol/*analogs & derivatives/poisoning MH - Female MH - Humans MH - Hypertension, Pulmonary/*drug therapy EDAT- 2009/03/17 09:00 MHDA- 2009/08/12 09:00 CRDT- 2009/03/17 09:00 PHST- 2008/07/02 00:00 [received] PHST- 2008/09/20 00:00 [revised] PHST- 2008/12/01 00:00 [accepted] PHST- 2009/03/17 09:00 [entrez] PHST- 2009/03/17 09:00 [pubmed] PHST- 2009/08/12 09:00 [medline] AID - S1053-2498(08)01746-4 [pii] AID - 10.1016/j.healun.2008.12.006 [doi] PST - ppublish SO - J Heart Lung Transplant. 2009 Mar;28(3):297-8. doi: 10.1016/j.healun.2008.12.006.