PMID- 19286166
OWN - NLM
STAT- MEDLINE
DCOM- 20100415
LR  - 20151119
IS  - 1879-1506 (Electronic)
IS  - 0003-9969 (Linking)
VI  - 54
IP  - 5
DP  - 2009 May
TI  - Gingival crevicular fluid levels of monocyte chemoattractant protein-1 in 
      periodontal health and disease.
PG  - 503-9
LID - 10.1016/j.archoralbio.2009.02.007 [doi]
AB  - OBJECTIVES: Monocyte chemoattractant protein-1 (MCP-1) stimulates the chemotaxis 
      of monocytes and also several cellular events associated with chemotaxis thus 
      causes recruitment of inflammatory cells. Its increased gingival crevicular fluid 
      (GCF) levels in periodontal disease have been reported in previous studies. The 
      present study has been carried out to assess the role of MCP-1 in periodontal 
      disease progression and also to determine the effect of periodontal treatment on 
      MCP-1 concentration in GCF. DESIGN: A total of 60 subjects were divided into 
      three groups (n=20) based on gingival index (GI), probing pocket depth (PPD) and 
      clinical attachment loss (CAL): healthy (group I), gingivitis (group II) and 
      chronic periodontitis (group III). A fourth group (group IV) consisted of 20 
      subjects from group III, 6-8 weeks after treatment (i.e. scaling and root 
      planing). GCF samples collected from each patient were quantified for MCP-1 using 
      ELISA. RESULTS: The mean MCP-1 concentration in GCF was found to be the highest 
      in group III, i.e. 72.60 pg/microl. The mean MCP-1 concentration in group I was 
      19.70 pg/microl and in group IV was 8.50 pg/microl. The mean MCP-1 concentration 
      (37.00 pg/microl) in group II was found to lie in between the concentrations 
      obtained in groups I and III. CONCLUSIONS: GCF MCP-1 levels increased 
      progressively with the progression of disease and decreased after treatment. 
      Levels of MCP-1 correlated positively with clinical parameters like GI, PPD and 
      CAL thus it can be considered as an inflammatory biomarker in periodontal disease 
      and also deserves further consideration as a therapeutic target.
FAU - Pradeep, A R
AU  - Pradeep AR
AD  - Department of Periodontics, Government Dental College and Research Institute, 
      Fort, Bangalore 560002, Karnataka, India. periodontics_gdc@yahoo.co.in
FAU - Daisy, Happy
AU  - Daisy H
FAU - Hadge, Parag
AU  - Hadge P
LA  - eng
PT  - Comparative Study
PT  - Journal Article
DEP - 20090316
PL  - England
TA  - Arch Oral Biol
JT  - Archives of oral biology
JID - 0116711
RN  - 0 (Biomarkers)
RN  - 0 (Chemokine CCL2)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Alveolar Bone Loss/classification/immunology/therapy
MH  - Biomarkers/analysis
MH  - Chemokine CCL2/*analysis
MH  - Chemotaxis, Leukocyte/immunology
MH  - Chronic Periodontitis/classification/immunology/therapy
MH  - Dental Scaling
MH  - Disease Progression
MH  - Female
MH  - Gingival Crevicular Fluid/*chemistry/immunology
MH  - Gingivitis/classification/immunology
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Periodontal Attachment Loss/classification/immunology
MH  - Periodontal Diseases/*immunology/therapy
MH  - Periodontal Index
MH  - Periodontal Pocket/classification/immunology
MH  - Periodontium/*immunology
MH  - Root Planing
EDAT- 2009/03/17 09:00
MHDA- 2010/04/16 06:00
CRDT- 2009/03/17 09:00
PHST- 2008/11/12 00:00 [received]
PHST- 2008/12/17 00:00 [revised]
PHST- 2009/02/16 00:00 [accepted]
PHST- 2009/03/17 09:00 [entrez]
PHST- 2009/03/17 09:00 [pubmed]
PHST- 2010/04/16 06:00 [medline]
AID - S0003-9969(09)00046-6 [pii]
AID - 10.1016/j.archoralbio.2009.02.007 [doi]
PST - ppublish
SO  - Arch Oral Biol. 2009 May;54(5):503-9. doi: 10.1016/j.archoralbio.2009.02.007. 
      Epub 2009 Mar 16.