PMID- 19286519
OWN - NLM
STAT- MEDLINE
DCOM- 20090429
LR  - 20240312
IS  - 1095-9203 (Electronic)
IS  - 0036-8075 (Print)
IS  - 0036-8075 (Linking)
VI  - 324
IP  - 5925
DP  - 2009 Apr 17
TI  - In vivo analysis of dendritic cell development and homeostasis.
PG  - 392-7
LID - 10.1126/science.1170540 [doi]
AB  - Dendritic cells (DCs) in lymphoid tissue arise from precursors that also produce 
      monocytes and plasmacytoid DCs (pDCs). Where DC and monocyte lineage commitment 
      occurs and the nature of the DC precursor that migrates from the bone marrow to 
      peripheral lymphoid organs are unknown. We show that DC development progresses 
      from the macrophage and DC precursor to common DC precursors that give rise to 
      pDCs and classical spleen DCs (cDCs), but not monocytes, and finally to committed 
      precursors of cDCs (pre-cDCs). Pre-cDCs enter lymph nodes through and migrate 
      along high endothelial venules and later disperse and integrate into the DC 
      network. Further cDC development involves cell division, which is controlled in 
      part by regulatory T cells and fms-like tyrosine kinase receptor-3.
FAU - Liu, Kang
AU  - Liu K
AD  - Laboratory of Molecular Immunology, Rockefeller University, New York, NY 10065, 
      USA. liuk@rockefeller.edu
FAU - Victora, Gabriel D
AU  - Victora GD
FAU - Schwickert, Tanja A
AU  - Schwickert TA
FAU - Guermonprez, Pierre
AU  - Guermonprez P
FAU - Meredith, Matthew M
AU  - Meredith MM
FAU - Yao, Kaihui
AU  - Yao K
FAU - Chu, Fei-Fan
AU  - Chu FF
FAU - Randolph, Gwendalyn J
AU  - Randolph GJ
FAU - Rudensky, Alexander Y
AU  - Rudensky AY
FAU - Nussenzweig, Michel
AU  - Nussenzweig M
LA  - eng
GR  - P01 AI051573-060004/AI/NIAID NIH HHS/United States
GR  - HHMI/Howard Hughes Medical Institute/United States
GR  - P01 AI051573-070004/AI/NIAID NIH HHS/United States
GR  - P01 AI051573-079005/AI/NIAID NIH HHS/United States
GR  - P01 AI051573-080004/AI/NIAID NIH HHS/United States
GR  - P01 AI051573-089005/AI/NIAID NIH HHS/United States
GR  - P01 AI051573-010004/AI/NIAID NIH HHS/United States
GR  - P01 AI051573-020004/AI/NIAID NIH HHS/United States
GR  - P01 AI051573-040004/AI/NIAID NIH HHS/United States
GR  - P01 AI051573-069005/AI/NIAID NIH HHS/United States
GR  - P01 AI051573-050004/AI/NIAID NIH HHS/United States
GR  - P01 AI051573/AI/NIAID NIH HHS/United States
GR  - P01 AI051573-030004/AI/NIAID NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20090312
PL  - United States
TA  - Science
JT  - Science (New York, N.Y.)
JID - 0404511
RN  - EC 2.7.10.1 (Flt3 protein, mouse)
RN  - EC 2.7.10.1 (fms-Like Tyrosine Kinase 3)
SB  - IM
MH  - Adoptive Transfer
MH  - Animals
MH  - Blood Vessels/cytology
MH  - Bone Marrow Cells/cytology
MH  - Cell Differentiation
MH  - Cell Division
MH  - Cell Lineage
MH  - Cell Movement
MH  - Cell Shape
MH  - Dendritic Cells/*cytology/immunology/physiology
MH  - Homeostasis
MH  - Lymph Nodes/blood supply/cytology/immunology
MH  - Lymphoid Tissue/blood supply/*cytology/immunology
MH  - Macrophages/cytology
MH  - Mice
MH  - Monocytes/*cytology
MH  - Myeloid Progenitor Cells/*cytology/physiology
MH  - Parabiosis
MH  - Signal Transduction
MH  - Spleen/cytology/immunology
MH  - T-Lymphocytes, Regulatory/physiology
MH  - Venules/cytology
MH  - fms-Like Tyrosine Kinase 3/genetics/metabolism
PMC - PMC2803315
MID - NIHMS149741
EDAT- 2009/03/17 09:00
MHDA- 2009/04/30 09:00
PMCR- 2010/01/07
CRDT- 2009/03/17 09:00
PHST- 2009/03/17 09:00 [entrez]
PHST- 2009/03/17 09:00 [pubmed]
PHST- 2009/04/30 09:00 [medline]
PHST- 2010/01/07 00:00 [pmc-release]
AID - 1170540 [pii]
AID - 10.1126/science.1170540 [doi]
PST - ppublish
SO  - Science. 2009 Apr 17;324(5925):392-7. doi: 10.1126/science.1170540. Epub 2009 Mar 
      12.