PMID- 19287455
OWN - NLM
STAT- MEDLINE
DCOM- 20090428
LR  - 20090911
IS  - 1476-5594 (Electronic)
IS  - 0950-9232 (Linking)
VI  - 28
IP  - 15
DP  - 2009 Apr 16
TI  - Tumor necrosis factor receptor-associated factor-1 enhances proinflammatory TNF 
      receptor-2 signaling and modifies TNFR1-TNFR2 cooperation.
PG  - 1769-81
LID - 10.1038/onc.2009.29 [doi]
AB  - It has been shown that tumor necrosis factor receptor-2 (TNFR2) stimulation leads 
      to degradation of TNF receptor associated factor-2 (TRAF2) and inhibition of 
      TNFR1-induced activation of NFkappaB and JNK. Here, we show that TRAF1 inhibits 
      TNFR2-induced proteasomal degradation of TRAF2 and relieves TNFR1-induced 
      activation of NFkappaB from the inhibitory effect of TNFR2. TRAF1 co-recruited 
      with TRAF2 to both TNF receptors. Despite lacking an amino-terminal 
      RING/zinc-finger domain, TRAF1 did not interfere with TNFR1-induced activation of 
      JNK and NFkappaB. It is noted that physiological expression levels of TRAF1 
      enhanced NFkappaB activation and interleukin-8 (IL8) production induced by TNFR2. 
      Thus, TRAF1 shifts the quality of integrated TNFR1-TNFR2 signaling from apoptosis 
      induction to proinflammatory NFkappaB signaling.
FAU - Wicovsky, A
AU  - Wicovsky A
AD  - Department of Internal Medicine II, Division of Molecular Internal Medicine, 
      University Hospital Wurzburg, Wurzburg, Germany.
FAU - Henkler, F
AU  - Henkler F
FAU - Salzmann, S
AU  - Salzmann S
FAU - Scheurich, P
AU  - Scheurich P
FAU - Kneitz, C
AU  - Kneitz C
FAU - Wajant, H
AU  - Wajant H
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20090316
PL  - England
TA  - Oncogene
JT  - Oncogene
JID - 8711562
RN  - 0 (Interleukin-8)
RN  - 0 (NF-kappa B)
RN  - 0 (Receptors, Tumor Necrosis Factor, Type I)
RN  - 0 (Receptors, Tumor Necrosis Factor, Type II)
RN  - 0 (TNF Receptor-Associated Factor 1)
RN  - 0 (TNF Receptor-Associated Factor 2)
SB  - IM
EIN - Oncogene. 2009 Aug 20;28(33):3008
MH  - Cell Line, Tumor
MH  - Humans
MH  - Interleukin-8/biosynthesis
MH  - NF-kappa B/metabolism
MH  - Receptors, Tumor Necrosis Factor, Type I/*physiology
MH  - Receptors, Tumor Necrosis Factor, Type II/*physiology
MH  - Signal Transduction/*physiology
MH  - TNF Receptor-Associated Factor 1/*physiology
MH  - TNF Receptor-Associated Factor 2/physiology
EDAT- 2009/03/17 09:00
MHDA- 2009/04/29 09:00
CRDT- 2009/03/17 09:00
PHST- 2009/03/17 09:00 [entrez]
PHST- 2009/03/17 09:00 [pubmed]
PHST- 2009/04/29 09:00 [medline]
AID - onc200929 [pii]
AID - 10.1038/onc.2009.29 [doi]
PST - ppublish
SO  - Oncogene. 2009 Apr 16;28(15):1769-81. doi: 10.1038/onc.2009.29. Epub 2009 Mar 16.