PMID- 19287949
OWN - NLM
STAT- MEDLINE
DCOM- 20090720
LR  - 20190606
IS  - 1019-6439 (Print)
IS  - 1019-6439 (Linking)
VI  - 34
IP  - 4
DP  - 2009 Apr
TI  - Significance of monocyte chemoattractant protein-1 in angiogenesis and survival 
      in colorectal liver metastases.
PG  - 923-30
AB  - Monocyte chemoattractant protein-1 (MCP-1) has been demonstrated to play a role 
      in tumor progression. The present study examined the MCP-1 expression of 
      colorectal liver metastases and determined whether MCP-1 is related to tumor 
      progression and is a predictive marker for survival after hepatic resection of 
      colorectal liver metastases. Eighty-seven patients with colorectal liver 
      metastases were evaluated by immunohistochemistry of MCP-1, Angiopoietin-2, CD68, 
      and CD34 for determination of microvessel density. Clinicopatholgical data were 
      also examined. In a separate experiment, immunohistochemistry of MCP-1 was 
      performed to investigate the expression of primary colorectal tumor according to 
      the clinical stage. MCP-1 mRNA expression was determined in colorectal cancer 
      cell lines. Forty-nine patients (56%) showed high expression of MCP-1 of 
      colorectal liver metastases. High MCP-1 expression was related to multiple 
      colorectal liver metastases. When the degree of MCP-1 expression increased, 
      microvessel density count significantly increased compared with low MCP-1 
      expression. The MCP-1 expression correlated with Angiopoietin-2 expression. MCP-1 
      expression of the primary colorectal cancer increased as the clinical stage 
      advanced. The increased MCP-1 mRNA expression was observed in cancer cell lines 
      which have high metastasis potency. Univariate analysis demonstrated that the 
      timing of metastases, tumor size, number of metastases, and MCP-1 expression were 
      significant prognostic factors. Multivariate analysis demonstrated that MCP-1 
      expression was a significant prognostic factor in hepatic disease-free survival. 
      The MCP-1 expression in colorectal liver metastases, at least in part, may be 
      associated with angiogenesis and be a predictive marker for hepatic recurrence 
      after hepatic resection for colorectal liver metastases.
FAU - Yoshidome, Hiroyuki
AU  - Yoshidome H
AD  - Department of General Surgery, Chiba University Graduate School of Medicine, 
      Chuo-ku, Chiba 260-8670, Japan. h-yoshidome@faculty.chiba-u.jp
FAU - Kohno, Hirohiko
AU  - Kohno H
FAU - Shida, Takashi
AU  - Shida T
FAU - Kimura, Fumio
AU  - Kimura F
FAU - Shimizu, Hiroaki
AU  - Shimizu H
FAU - Ohtsuka, Masayuki
AU  - Ohtsuka M
FAU - Nakatani, Yukio
AU  - Nakatani Y
FAU - Miyazaki, Masaru
AU  - Miyazaki M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Greece
TA  - Int J Oncol
JT  - International journal of oncology
JID - 9306042
RN  - 0 (Angiopoietin-2)
RN  - 0 (Antigens, CD)
RN  - 0 (Antigens, CD34)
RN  - 0 (Antigens, Differentiation, Myelomonocytic)
RN  - 0 (CD68 antigen, human)
RN  - 0 (Chemokine CCL2)
SB  - IM
MH  - Aged
MH  - Angiopoietin-2/biosynthesis
MH  - Antigens, CD/biosynthesis
MH  - Antigens, CD34/biosynthesis
MH  - Antigens, Differentiation, Myelomonocytic/biosynthesis
MH  - Chemokine CCL2/metabolism/*physiology
MH  - Colorectal Neoplasms/*metabolism/mortality/*pathology
MH  - Disease-Free Survival
MH  - Female
MH  - *Gene Expression Regulation, Neoplastic
MH  - Humans
MH  - Liver Neoplasms/*metabolism/mortality/*pathology/secondary
MH  - Male
MH  - Middle Aged
MH  - *Neovascularization, Pathologic
MH  - Treatment Outcome
EDAT- 2009/03/17 09:00
MHDA- 2009/07/21 09:00
CRDT- 2009/03/17 09:00
PHST- 2009/03/17 09:00 [entrez]
PHST- 2009/03/17 09:00 [pubmed]
PHST- 2009/07/21 09:00 [medline]
AID - 10.3892/ijo_00000218 [doi]
PST - ppublish
SO  - Int J Oncol. 2009 Apr;34(4):923-30. doi: 10.3892/ijo_00000218.