PMID- 19288009
OWN - NLM
STAT- MEDLINE
DCOM- 20090618
LR  - 20190606
IS  - 1021-335X (Print)
IS  - 1021-335X (Linking)
VI  - 21
IP  - 4
DP  - 2009 Apr
TI  - Clinical comparison of QOL and adverse events during postoperative adjuvant 
      chemotherapy in outpatients with node-positive colorectal cancer or gastric 
      cancer.
PG  - 1061-6
AB  - The aim of this study was to evaluate the quality of life (QOL) from the 
      performance status (PS) and face scale (FS), and to compare adverse events (AEs) 
      during chemotherapy in 28 patients with node-positive colorectal cancer (NP-CRC) 
      and 15 patients with node-positive gastric cancer (NP-GC). The anticancer regimen 
      consisted of 5-FU/LV+CPT-11 for NP-CRC and 5-FU+low-dose CDDP for NP-GC. Results 
      were evaluated after completion of three courses. QOL evaluation revealed no 
      significant differences between the two groups with respect to PS and FS. Among 
      hematological AEs, grade 1/2 mild leucopenia was significantly more common in 
      NP-CRC than NP-GC patients (p<0.05), while grade 1/2 mild thrombocytopenia was 
      significantly more common in NP-GC than NP-CRC patients (p<0.05). Among 
      non-hematological AEs, grade 1/2 mild neuropathy (olfactory nerve) was 
      significantly more common in NP-CRC than NP-GC patients (p<0.05). The monthly 
      cost for one course was approximately euro586.8 for NP-CRC patients and 
      approximately euro181.8 for NP-GC patients. These results suggest that first-line 
      postoperative outpatient adjuvant chemotherapy for NP-CRC and NP-GC shows no 
      significant differences with respect to QOL, but both AEs and the cost are higher 
      for NP-CRC than for NP-GC.
FAU - Mukai, Masaya
AU  - Mukai M
AD  - Tokai University Hachioji Hospital, Department of Surgery, Tokyo 192-0032, Japan. 
      mukai.masaya@hachioji-hosp.tokai.ac.jp
FAU - Kishima, Kyoko
AU  - Kishima K
FAU - Uchiumi, Fumino
AU  - Uchiumi F
FAU - Ishibashi, Emi
AU  - Ishibashi E
FAU - Fukasawa, Maki
AU  - Fukasawa M
FAU - Tajima, Takayuki
AU  - Tajima T
FAU - Nakamura, Masato
AU  - Nakamura M
FAU - Makuuchi, Hiroyasu
AU  - Makuuchi H
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Greece
TA  - Oncol Rep
JT  - Oncology reports
JID - 9422756
SB  - IM
MH  - Antineoplastic Combined Chemotherapy Protocols/adverse effects
MH  - Chemotherapy, Adjuvant/adverse effects
MH  - Colorectal Neoplasms/*drug therapy/psychology
MH  - Combined Modality Therapy
MH  - Humans
MH  - Lymphatic Metastasis
MH  - *Quality of Life
MH  - Stomach Neoplasms/*drug therapy/psychology
EDAT- 2009/03/17 09:00
MHDA- 2009/06/19 09:00
CRDT- 2009/03/17 09:00
PHST- 2009/03/17 09:00 [entrez]
PHST- 2009/03/17 09:00 [pubmed]
PHST- 2009/06/19 09:00 [medline]
AID - 10.3892/or_00000324 [doi]
PST - ppublish
SO  - Oncol Rep. 2009 Apr;21(4):1061-6. doi: 10.3892/or_00000324.