PMID- 19288449
OWN - NLM
STAT- MEDLINE
DCOM- 20090420
LR  - 20211020
IS  - 1098-2825 (Electronic)
IS  - 0887-8013 (Print)
IS  - 0887-8013 (Linking)
VI  - 23
IP  - 2
DP  - 2009
TI  - Interleukin-18 gene 105A/C genetic polymorphism is associated with the 
      susceptibility of Kawasaki disease.
PG  - 71-6
LID - 10.1002/jcla.20292 [doi]
AB  - Interleukin-18 (IL-18)-656T/G, -607A/C, and -137C/G promoter polymorphisms had 
      been reported associated with Kawasaki disease (KD). An IL-18 genetic A/C 
      polymorphism at coding position 105 (rs549908) has been linked with asthma, 
      rheumatoid, and systemic lupus erythematosus. We tested a hypothesis that the 
      IL-18 105A/C genetic polymorphism confers KD susceptibility. Study participants 
      were Taiwanese KD patients and a healthy control group. Our data indicated that 
      the frequency of C allele was significantly higher in the patient group (13.9%) 
      than in the control group (2.7%; P<0.0001, odds ratio [OR]=5.93; 95% confidence 
      interval [CI]=2.57-13.73). Therefore, persons with the C allele may have higher 
      risk of developing KD. In addition, compared with the haplotype frequencies 
      between case and control groups, the KD patients with TACC haplotype appeared to 
      be a significant "at-risk" haplotype compared with other haplotypes (OR: 4.62, 
      95% CI: 1.71-12.43; P=0.001). KD patient with the TAGA haplotype appeared to be a 
      significant "protective" haplotype compared with other haplotypes (OR: 0.51, 95% 
      CI:0.29-0.89; P=0.017). Our results suggest that 105A/C polymorphism and the 
      haplotypes in IL-18 gene are associated with the risk of KD in Taiwanese 
      population.
CI  - (c) 2009 Wiley-Liss, Inc.
FAU - Chen, Shih-Yin
AU  - Chen SY
AD  - Department of Medical Research, Department of Medical Genetics, China Medical 
      University Hospital, No. 2 Yuh Der Road, Taichung, Taiwan.
FAU - Wan, Lei
AU  - Wan L
FAU - Huang, Yu-Chuen
AU  - Huang YC
FAU - Sheu, Jim Jinn-Chyuan
AU  - Sheu JJ
FAU - Lan, Yu-Ching
AU  - Lan YC
FAU - Lai, Chih-Ho
AU  - Lai CH
FAU - Lin, Cheng-Wen
AU  - Lin CW
FAU - Chang, Jeng Sheng
AU  - Chang JS
FAU - Tsai, Yuhsin
AU  - Tsai Y
FAU - Liu, Shih-Ping
AU  - Liu SP
FAU - Lin, Ying-Ju
AU  - Lin YJ
FAU - Tsai, Fuu-Jen
AU  - Tsai FJ
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Clin Lab Anal
JT  - Journal of clinical laboratory analysis
JID - 8801384
RN  - 0 (Interleukin-18)
SB  - IM
MH  - Chi-Square Distribution
MH  - Child
MH  - Child, Preschool
MH  - Coronary Vessels/pathology
MH  - Female
MH  - Gene Frequency
MH  - Genetic Predisposition to Disease/*epidemiology
MH  - Haplotypes
MH  - Humans
MH  - Infant
MH  - Interleukin-18/*genetics
MH  - Logistic Models
MH  - Male
MH  - Mucocutaneous Lymph Node Syndrome/*epidemiology/*genetics
MH  - *Polymorphism, Single Nucleotide
MH  - Taiwan/epidemiology
PMC - PMC6649070
EDAT- 2009/03/17 09:00
MHDA- 2009/04/21 09:00
PMCR- 2009/03/13
CRDT- 2009/03/17 09:00
PHST- 2009/03/17 09:00 [entrez]
PHST- 2009/03/17 09:00 [pubmed]
PHST- 2009/04/21 09:00 [medline]
PHST- 2009/03/13 00:00 [pmc-release]
AID - JCLA20292 [pii]
AID - 10.1002/jcla.20292 [doi]
PST - ppublish
SO  - J Clin Lab Anal. 2009;23(2):71-6. doi: 10.1002/jcla.20292.