PMID- 19289123
OWN - NLM
STAT- MEDLINE
DCOM- 20090414
LR  - 20181201
IS  - 1873-3468 (Electronic)
IS  - 0014-5793 (Linking)
VI  - 583
IP  - 7
DP  - 2009 Apr 2
TI  - Interleukin-1beta is a positive regulator of TIARP/STAMP2 gene and protein 
      expression in adipocytes in vitro.
PG  - 1196-200
LID - 10.1016/j.febslet.2009.03.015 [doi]
AB  - The impact of interleukin (IL)-1beta on tumor necrosis factor alpha-induced 
      adipose-related protein (TIARP)/six-transmembrane protein of prostate 2 (STAMP2) 
      was determined in adipocytes. TIARP/STAMP2 mRNA synthesis was significantly 
      stimulated by IL-1beta in a dose- and time-dependent fashion in 3T3-L1 
      adipocytes. Signaling studies suggested that janus kinase 2, nuclear factor 
      kappaB, and p44/42 mitogen-activated protein kinase are involved in 
      IL-1beta-induced TIARP/STAMP2 mRNA expression. Furthermore, IL-1beta, TNFalpha, 
      and IL-6 showed synergistic stimulatory effects on TIARP/STAMP2 gene expression. 
      Moreover, both TIARP/STAMP2 mRNA synthesis and protein expression were induced by 
      IL-1beta in fully differentiated human mesenchymal stem cell-derived adipocytes 
      (hMSC-Ad). Taken together, TIARP/STAMP2 is highly upregulated in 3T3-L1 cells and 
      hMSC-Ad by IL-1beta and might, therefore, modulate proinflammatory and insulin 
      resistance-inducing effects of IL-1beta.
FAU - Kralisch, Susan
AU  - Kralisch S
AD  - University of Leipzig, Department of Internal Medicine III, Leipzig, Germany.
FAU - Sommer, Grit
AU  - Sommer G
FAU - Weise, Sebastian
AU  - Weise S
FAU - Lipfert, Jana
AU  - Lipfert J
FAU - Lossner, Ulrike
AU  - Lossner U
FAU - Kamprad, Manja
AU  - Kamprad M
FAU - Schrock, Kathleen
AU  - Schrock K
FAU - Bluher, Matthias
AU  - Bluher M
FAU - Stumvoll, Michael
AU  - Stumvoll M
FAU - Fasshauer, Mathias
AU  - Fasshauer M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20090314
PL  - England
TA  - FEBS Lett
JT  - FEBS letters
JID - 0155157
RN  - 0 (IL6 protein, human)
RN  - 0 (Interleukin-1beta)
RN  - 0 (Interleukin-6)
RN  - 0 (Membrane Proteins)
RN  - 0 (NF-kappa B)
RN  - 0 (RNA, Messenger)
RN  - 0 (Tiarp protein, mouse)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - EC 1.- (Oxidoreductases)
RN  - EC 1.16.1.- (STEAP4 protein, human)
RN  - EC 2.7.10.2 (JAK2 protein, human)
RN  - EC 2.7.10.2 (Jak2 protein, mouse)
RN  - EC 2.7.10.2 (Janus Kinase 2)
RN  - EC 2.7.11.24 (Mitogen-Activated Protein Kinase 1)
SB  - IM
MH  - 3T3-L1 Cells
MH  - Adipocytes/cytology/*metabolism
MH  - Animals
MH  - Cell Differentiation/drug effects/physiology
MH  - Dose-Response Relationship, Drug
MH  - Drug Synergism
MH  - Gene Expression Regulation/*drug effects/physiology
MH  - Humans
MH  - Insulin Resistance/physiology
MH  - Interleukin-1beta/agonists/*pharmacology
MH  - Interleukin-6/agonists/pharmacology
MH  - Janus Kinase 2/metabolism
MH  - Membrane Proteins/*biosynthesis
MH  - Mesenchymal Stem Cells/cytology/metabolism
MH  - Mice
MH  - Mitogen-Activated Protein Kinase 1/metabolism
MH  - NF-kappa B/metabolism
MH  - Oxidoreductases/*biosynthesis
MH  - RNA, Messenger/biosynthesis
MH  - Tumor Necrosis Factor-alpha/agonists/pharmacology
EDAT- 2009/03/18 09:00
MHDA- 2009/04/15 09:00
CRDT- 2009/03/18 09:00
PHST- 2009/02/06 00:00 [received]
PHST- 2009/03/01 00:00 [revised]
PHST- 2009/03/05 00:00 [accepted]
PHST- 2009/03/18 09:00 [entrez]
PHST- 2009/03/18 09:00 [pubmed]
PHST- 2009/04/15 09:00 [medline]
AID - S0014-5793(09)00185-9 [pii]
AID - 10.1016/j.febslet.2009.03.015 [doi]
PST - ppublish
SO  - FEBS Lett. 2009 Apr 2;583(7):1196-200. doi: 10.1016/j.febslet.2009.03.015. Epub 
      2009 Mar 14.