PMID- 19289188
OWN - NLM
STAT- MEDLINE
DCOM- 20090623
LR  - 20211028
IS  - 0065-308X (Print)
IS  - 0065-308X (Linking)
VI  - 68
DP  - 2009
TI  - HLA-mediated control of HIV and HIV adaptation to HLA.
PG  - 1-20
LID - 10.1016/S0065-308X(08)00601-5 [doi]
AB  - The human immunodeficiency virus (HIV) epidemic provides a rare opportunity to 
      examine in detail the initial stages of a host-pathogen co-evolutionary struggle 
      in humans. The genes encoding the human leukocyte antigen (HLA) class I molecules 
      have a critical influence in the success or failure of the immune response 
      against HIV. The particular HLA class I molecules expressed by each individual 
      defines the type of cytotoxic T-lymphocyte (CTL) response that is made against 
      the virus. This chapter describes the role of HLA class I and the CTL response in 
      controlling HIV replication, and discusses the extent to which HIV has already 
      adapted to those HLA class I molecules and CTL responses that are most effective 
      in viral suppression. It is evident that viral mutations that enable HIV to evade 
      the CTL response are indeed already accumulating in populations where the 
      selecting HLA molecules are highly prevalent, indicating the dynamic and shifting 
      nature of the evolutionary interplay between HIV and human populations.
FAU - Payne, Rebecca P
AU  - Payne RP
AD  - Department of Paediatrics, University of Oxford, Peter Medawar Building for 
      Pathogen Research, Oxford, United Kingdom.
FAU - Matthews, Philippa C
AU  - Matthews PC
FAU - Prado, Julia G
AU  - Prado JG
FAU - Goulder, Philip J R
AU  - Goulder PJ
LA  - eng
GR  - G0501777/MRC_/Medical Research Council/United Kingdom
PT  - Journal Article
PL  - England
TA  - Adv Parasitol
JT  - Advances in parasitology
JID - 0370435
RN  - 0 (HLA Antigens)
RN  - 0 (gag Gene Products, Human Immunodeficiency Virus)
SB  - IM
MH  - Adaptation, Physiological/*genetics
MH  - Biological Evolution
MH  - HIV Infections/*immunology/*virology
MH  - HIV-1/*genetics/physiology
MH  - HLA Antigens/*genetics/*immunology
MH  - Humans
MH  - Protein Footprinting
MH  - T-Lymphocytes, Cytotoxic/physiology
MH  - Viremia
MH  - gag Gene Products, Human Immunodeficiency Virus/metabolism
EDAT- 2009/03/18 09:00
MHDA- 2009/06/24 09:00
CRDT- 2009/03/18 09:00
PHST- 2009/03/18 09:00 [entrez]
PHST- 2009/03/18 09:00 [pubmed]
PHST- 2009/06/24 09:00 [medline]
AID - S0065-308X(08)00601-5 [pii]
AID - 10.1016/S0065-308X(08)00601-5 [doi]
PST - ppublish
SO  - Adv Parasitol. 2009;68:1-20. doi: 10.1016/S0065-308X(08)00601-5.