PMID- 19290926
OWN - NLM
STAT- MEDLINE
DCOM- 20090416
LR  - 20211028
IS  - 1600-065X (Electronic)
IS  - 0105-2896 (Print)
IS  - 0105-2896 (Linking)
VI  - 228
IP  - 1
DP  - 2009 Mar
TI  - The tyrosine kinase network regulating mast cell activation.
PG  - 149-69
LID - 10.1111/j.1600-065X.2008.00742.x [doi]
AB  - Mast cell mediator release represents a pivotal event in the initiation of 
      inflammatory reactions associated with allergic disorders. These responses follow 
      antigen-mediated aggregation of immunoglobulin E (IgE)-occupied high-affinity 
      receptors for IgE (Fc epsilon RI) on the mast cell surface, a response which can 
      be further enhanced following stem cell factor-induced ligation of the mast cell 
      growth factor receptor KIT (CD117). Activation of tyrosine kinases is central to 
      the ability of both Fc epsilon RI and KIT to transmit downstream signaling events 
      required for the regulation of mast cell activation. Whereas KIT possesses 
      inherent tyrosine kinase activity, Fc epsilon RI requires the recruitment of Src 
      family tyrosine kinases and Syk to control the early receptor-proximal signaling 
      events. The signaling pathways propagated by these tyrosine kinases can be 
      further upregulated by the Tec kinase Bruton's tyrosine kinase and downregulated 
      by the actions of the tyrosine Src homology 2 domain-containing phosphatase 1 
      (SHP-1) and SHP-2. In this review, we discuss the regulation and role of specific 
      members of this tyrosine kinase network in KIT and Fc epsilon RI-mediated mast 
      cell activation.
FAU - Gilfillan, Alasdair M
AU  - Gilfillan AM
AD  - Laboratory of Allergic Diseases, National Institute of Allergy and Infectious 
      Diseases, National Institutes of Health, Bethesda, MD 20892-1930, USA.
FAU - Rivera, Juan
AU  - Rivera J
LA  - eng
GR  - Z01 AR041101-14/ImNIH/Intramural NIH HHS/United States
GR  - Z01 AR041155-01/ImNIH/Intramural NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Intramural
PT  - Review
PL  - England
TA  - Immunol Rev
JT  - Immunological reviews
JID - 7702118
RN  - 0 (Intracellular Signaling Peptides and Proteins)
RN  - EC 2.7.10.1 (Protein-Tyrosine Kinases)
RN  - EC 2.7.10.2 (SYK protein, human)
RN  - EC 2.7.10.2 (Syk Kinase)
SB  - IM
MH  - Animals
MH  - Humans
MH  - Intracellular Signaling Peptides and Proteins
MH  - Mast Cells/*cytology/*immunology
MH  - Protein-Tyrosine Kinases/*metabolism
MH  - *Signal Transduction
MH  - Syk Kinase
PMC - PMC2669301
MID - NIHMS100232
EDAT- 2009/03/18 09:00
MHDA- 2009/04/17 09:00
PMCR- 2010/03/01
CRDT- 2009/03/18 09:00
PHST- 2009/03/18 09:00 [entrez]
PHST- 2009/03/18 09:00 [pubmed]
PHST- 2009/04/17 09:00 [medline]
PHST- 2010/03/01 00:00 [pmc-release]
AID - IMR742 [pii]
AID - 10.1111/j.1600-065X.2008.00742.x [doi]
PST - ppublish
SO  - Immunol Rev. 2009 Mar;228(1):149-69. doi: 10.1111/j.1600-065X.2008.00742.x.