PMID- 19291400
OWN - NLM
STAT- MEDLINE
DCOM- 20100311
LR  - 20220309
IS  - 1573-2568 (Electronic)
IS  - 0163-2116 (Print)
IS  - 0163-2116 (Linking)
VI  - 55
IP  - 3
DP  - 2010 Mar
TI  - Reproducibility and performance characteristics of colonic compliance, tone, and 
      sensory tests in healthy humans.
PG  - 709-15
LID - 10.1007/s10620-009-0772-x [doi]
AB  - BACKGROUND: The performance characteristics of colonic sensation and motility 
      measurements are unclear. AIM: To compare left colon compliance, tone, and 
      sensation in males and females and to evaluate inter and intra-individual 
      coefficients of variation (COV) in these measurements. METHODS: Data were 
      acquired using standard barostat methods, by one technologist, in 72 human 
      volunteers (38 males, 18-65 years). We measured compliance, fasting tone, and 
      sensation during baseline and post-placebo; postprandial (PP) tone was measured 
      only post-placebo. Compliance and thresholds for first sensation, gas, and pain 
      were measured using ascending method of limits; sensory ratings (0-100 mm VAS) 
      using random phasic distensions at 8-36 mmHg above baseline operating pressure. 
      Change in PP tone was measured by barostat balloon volume for the first 30 min 
      after a 1000-kcal meal. Inter-COV was calculated as 100 (SD/mean), and intra-COV 
      as (100 x SD delta/overall mean). RESULTS: There were no statistically 
      significant associations with gender for most sensory or motor data at baseline. 
      A modest association of fasting colonic tone and gender was observed. COV are 
      lower (20-35%) for compliance, fasting tone, pain threshold, and sensation 
      ratings than for PP tone and threshold for first or gas sensation (>45%). COV 
      data are similar in males and females; sensation COVs appear smaller in females 
      than in males. CONCLUSIONS: Testing of compliance, tone and pain, and gas 
      sensation in left colon performs adequately to assess these functions in humans. 
      Lower COV for sensation tests among females is relevant to plan studies of drugs 
      intended for functional GI disorders.
FAU - Odunsi, Suwebatu T
AU  - Odunsi ST
AD  - Clinical Enteric Neuroscience Translational and Epidemiological Research 
      (C.E.N.T.E.R.), College of Medicine, Mayo Clinic, Charlton 8-110, Rochester, MN 
      55905, USA.
FAU - Camilleri, Michael
AU  - Camilleri M
FAU - Bharucha, Adil E
AU  - Bharucha AE
FAU - Papathanasopoulos, Athanasios
AU  - Papathanasopoulos A
FAU - Busciglio, Irene
AU  - Busciglio I
FAU - Burton, Duane
AU  - Burton D
FAU - Zinsmeister, Alan R
AU  - Zinsmeister AR
LA  - eng
GR  - K24-DK02638/DK/NIDDK NIH HHS/United States
GR  - R01 DK067071-05/DK/NIDDK NIH HHS/United States
GR  - K24 DK002638/DK/NIDDK NIH HHS/United States
GR  - R01-DK67071/DK/NIDDK NIH HHS/United States
GR  - K24 DK002638-10/DK/NIDDK NIH HHS/United States
GR  - R01 DK067071/DK/NIDDK NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20090317
PL  - United States
TA  - Dig Dis Sci
JT  - Digestive diseases and sciences
JID - 7902782
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Colon/innervation/*physiology
MH  - Compliance
MH  - Fasting/physiology
MH  - Female
MH  - Humans
MH  - Individuality
MH  - Male
MH  - Middle Aged
MH  - Muscle Tonus/physiology
MH  - Pain/physiopathology
MH  - Reproducibility of Results
MH  - Sensation/physiology
MH  - Sensory Thresholds/physiology
MH  - Sex Factors
PMC - PMC2824021
MID - NIHMS111388
EDAT- 2009/03/18 09:00
MHDA- 2010/03/12 06:00
PMCR- 2010/09/01
CRDT- 2009/03/18 09:00
PHST- 2008/12/23 00:00 [received]
PHST- 2009/02/11 00:00 [accepted]
PHST- 2009/03/18 09:00 [entrez]
PHST- 2009/03/18 09:00 [pubmed]
PHST- 2010/03/12 06:00 [medline]
PHST- 2010/09/01 00:00 [pmc-release]
AID - 10.1007/s10620-009-0772-x [doi]
PST - ppublish
SO  - Dig Dis Sci. 2010 Mar;55(3):709-15. doi: 10.1007/s10620-009-0772-x. Epub 2009 Mar 
      17.