PMID- 19293593
OWN - NLM
STAT- MEDLINE
DCOM- 20090715
LR  - 20090507
IS  - 1660-2110 (Electronic)
IS  - 1660-2110 (Linking)
VI  - 111
IP  - 4
DP  - 2009
TI  - Clinical interpretation of reticulocyte hemoglobin content, RET-Y, in chronic 
      hemodialysis patients.
PG  - c247-52
LID - 10.1159/000209151 [doi]
AB  - BACKGROUND: Iron deficiency is the most common factor associated with 
      erythropoietin (EPO) hyporesponsiveness. Current iron indices are inadequate to 
      demonstrate the status or utility of iron in erythropoiesis. The aims of this 
      study are to investigate the value of the reticulocyte hemoglobin content, RET-Y, 
      in hemodialysis (HD) patients and compare the levels with conventional iron 
      indices. METHODS: HD patients (n = 289) were divided into 4 groups according to 
      serum ferritin (cutoff value 100 ng/ml) and transferrin saturation (TSAT, cutoff 
      value 20%). The RET-Y value, hemogram and biochemical data were determined and 
      compared between groups. Factors associated with RET-Y were examined. RESULTS: 
      The mean RET-Y value was 1,716 +/- 125 AU. Patients with absolute iron deficiency 
      had lower RET-Y levels and mean corpuscular volume (MCV). Patients with 
      functional iron deficiency had a lower reticulocyte production index and serum 
      albumin levels. MCV, mean corpuscular hemoglobin concentration (MCHC) and albumin 
      were independently correlated with the RET-Y level (all p < 0.001). 
      EPO-independent patients had low iron indices and low RET-Y levels, but a higher 
      reticulocyte production index and albumin levels were noted. CONCLUSION: RET-Y 
      levels in HD patients were close to that of the normal population. Low RET-Y 
      levels were observed in patients with absolute iron deficiency and also in 
      EPO-independent patients with low ferritin and low TSAT. There was a strong 
      association between the serum albumin and RET-Y levels in chronic HD patients.
CI  - Copyright (c) 2009 S. Karger AG, Basel.
FAU - Ng, Hwee-Yeong
AU  - Ng HY
AD  - Division of Nephrology, Department of Internal Medicine, Chang Gung Memorial 
      Hospital, Kaohsiung Medical Center, 123 Ta-Pei Road, Niao-Sung Hsiang, Kaohsiung 
      Hsien 833, Taiwan.
FAU - Chen, Hung-Chun
AU  - Chen HC
FAU - Pan, Lin-Lin
AU  - Pan LL
FAU - Tsai, Yu-Che
AU  - Tsai YC
FAU - Hsu, Kao-Tai
AU  - Hsu KT
FAU - Liao, Shang-Chih
AU  - Liao SC
FAU - Chuang, Fong-Rong
AU  - Chuang FR
FAU - Chen, Jin-Bor
AU  - Chen JB
FAU - Lee, Chien-Te
AU  - Lee CT
LA  - eng
PT  - Controlled Clinical Trial
PT  - Journal Article
DEP - 20090317
PL  - Switzerland
TA  - Nephron Clin Pract
JT  - Nephron. Clinical practice
JID - 101159763
RN  - 0 (Hemoglobins)
SB  - IM
MH  - Anemia, Iron-Deficiency/blood/*complications/*diagnosis
MH  - Female
MH  - Hemoglobins/*analysis
MH  - Humans
MH  - Kidney Failure, Chronic/blood/*complications/*diagnosis
MH  - Male
MH  - Middle Aged
MH  - *Renal Dialysis
MH  - Reproducibility of Results
MH  - Reticulocytes/*metabolism
MH  - Sensitivity and Specificity
EDAT- 2009/03/19 09:00
MHDA- 2009/07/16 09:00
CRDT- 2009/03/19 09:00
PHST- 2008/05/13 00:00 [received]
PHST- 2008/10/03 00:00 [accepted]
PHST- 2009/03/19 09:00 [entrez]
PHST- 2009/03/19 09:00 [pubmed]
PHST- 2009/07/16 09:00 [medline]
AID - 000209151 [pii]
AID - 10.1159/000209151 [doi]
PST - ppublish
SO  - Nephron Clin Pract. 2009;111(4):c247-52. doi: 10.1159/000209151. Epub 2009 Mar 
      17.