PMID- 19294304
OWN - NLM
STAT- MEDLINE
DCOM- 20090521
LR  - 20090318
IS  - 1473-0197 (Print)
IS  - 1473-0189 (Linking)
VI  - 9
IP  - 7
DP  - 2009 Apr 7
TI  - The deformation of flexible PDMS microchannels under a pressure driven flow.
PG  - 935-8
LID - 10.1039/b813061b [doi]
AB  - Poly(dimethylsiloxane) (PDMS) microchannels are commonly used microfluidic 
      structures that have a wide variety of biological testing applications, including 
      the simulation of blood vessels to study the mechanics of vascular disease. In 
      these studies in particular, the deformation of the channel due to the pressure 
      inside is a critical parameter. We describe a method for using fluorescence 
      microscopy to quantify the deformation of such channels under pressure driven 
      flow. Additionally, the relationship between wall thickness and channel 
      deformation is investigated. PDMS microchannels of varying top wall thickness 
      were created using a soft lithography process. A solution of fluorescent dye is 
      pumped through the channels at constant volume flow rates and illuminated. 
      Pressure and fluorescence intensity are measured at five positions along the 
      length of the channel. Fluorescence measurements are then used to determine 
      deformation, using the linear relationship of dye layer thickness and intensity. 
      A linear relationship between pressure and microchannel deformation is measured. 
      Pressure drops and deformations closely correspond to values predicted by the 
      model in most cases. Additionally, measured pressure drops are found to be up to 
      35% less than the pressure drop in a rigid-walled channel, and channel wall 
      thickness is found to have an increasing effect as the channel wall thickness 
      decreases.
FAU - Hardy, Brian S
AU  - Hardy BS
AD  - University of California Los Angeles, 420 Westwood Plaza, Los Angeles, CA, USA.
FAU - Uechi, Kawika
AU  - Uechi K
FAU - Zhen, Janet
AU  - Zhen J
FAU - Pirouz Kavehpour, H
AU  - Pirouz Kavehpour H
LA  - eng
PT  - Journal Article
DEP - 20081219
PL  - England
TA  - Lab Chip
JT  - Lab on a chip
JID - 101128948
RN  - 0 (Dimethylpolysiloxanes)
SB  - IM
MH  - Computer Simulation
MH  - Dimethylpolysiloxanes/*chemistry
MH  - Equipment Design
MH  - Flow Injection Analysis
MH  - Microfluidic Analytical Techniques/instrumentation/*methods
MH  - Microfluidics/instrumentation/*methods
MH  - Microscopy, Fluorescence
MH  - *Pressure
EDAT- 2009/03/19 09:00
MHDA- 2009/05/22 09:00
CRDT- 2009/03/19 09:00
PHST- 2009/03/19 09:00 [entrez]
PHST- 2009/03/19 09:00 [pubmed]
PHST- 2009/05/22 09:00 [medline]
AID - 10.1039/b813061b [doi]
PST - ppublish
SO  - Lab Chip. 2009 Apr 7;9(7):935-8. doi: 10.1039/b813061b. Epub 2008 Dec 19.