PMID- 19295238 OWN - NLM STAT- MEDLINE DCOM- 20090810 LR - 20211028 IS - 1423-0097 (Electronic) IS - 1018-2438 (Linking) VI - 149 IP - 4 DP - 2009 TI - Association analysis of brain-derived neurotrophic factor gene polymorphisms in asthmatic families. PG - 343-9 LID - 10.1159/000205580 [doi] AB - BACKGROUND: A role for neuronal modulation of inflammation and airway hyper-responsiveness has been well described in asthma, and neurotrophins provide the link between inflammation and neuronal dysfunction. Brain-derived neurotrophic factor (BDNF) is an important mediator in this interaction. The aim of this study was to analyze the possible relationship between polymorphisms of the gene encoding BDNF and susceptibility to asthma. METHODS: 341 families with at least 2 siblings with asthma were genotyped for 4 BDNF polymorphisms (rs6265, rs2030324, rs988748 and rs7124442). RESULTS: Analysis by family-based association tests revealed no significant association between any polymorphisms analyzed and asthma susceptibility. Furthermore, BDNF polymorphism was not associated with asthma-related phenotypes such as FEV(1) % predicted, bronchial hyper-responsiveness, IgE level, asthma and atopy severity scores. CONCLUSIONS: Our results suggest that genetic variation in the BDNF gene does not contribute significantly to asthma susceptibility or severity. CI - Copyright (C) 2009 S. Karger AG, Basel. FAU - Szczepankiewicz, Aleksandra AU - Szczepankiewicz A AD - Department of Pediatric Pulmonology, Allergy and Clinical Immunology, Third Department of Pediatrics, Poznan University of Medical Sciences, PL-60-572 Poznan, Poland. alszczep@amp.edu.pl FAU - Rose-Zerilli, Matthew J AU - Rose-Zerilli MJ FAU - Barton, Sheila J AU - Barton SJ FAU - Holgate, Stephen T AU - Holgate ST FAU - Holloway, John W AU - Holloway JW LA - eng GR - G0800766/MRC_/Medical Research Council/United Kingdom PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20090317 PL - Switzerland TA - Int Arch Allergy Immunol JT - International archives of allergy and immunology JID - 9211652 RN - 0 (Brain-Derived Neurotrophic Factor) RN - 37341-29-0 (Immunoglobulin E) SB - IM MH - Asthma/*epidemiology/*genetics MH - Brain-Derived Neurotrophic Factor/*genetics MH - Gene Frequency/genetics MH - *Genetic Predisposition to Disease MH - Haplotypes/genetics MH - Humans MH - Immunoglobulin E/blood MH - Linkage Disequilibrium/genetics MH - Polymorphism, Single Nucleotide MH - United Kingdom/epidemiology EDAT- 2009/03/20 09:00 MHDA- 2009/08/11 09:00 CRDT- 2009/03/20 09:00 PHST- 2008/06/02 00:00 [received] PHST- 2008/10/21 00:00 [accepted] PHST- 2009/03/20 09:00 [entrez] PHST- 2009/03/20 09:00 [pubmed] PHST- 2009/08/11 09:00 [medline] AID - 000205580 [pii] AID - 10.1159/000205580 [doi] PST - ppublish SO - Int Arch Allergy Immunol. 2009;149(4):343-9. doi: 10.1159/000205580. Epub 2009 Mar 17.