PMID- 19295451
OWN - NLM
STAT- MEDLINE
DCOM- 20090616
LR  - 20211020
IS  - 1473-558X (Electronic)
IS  - 0959-4965 (Print)
IS  - 0959-4965 (Linking)
VI  - 20
IP  - 6
DP  - 2009 Apr 22
TI  - Dopamine D1-like receptor activation induces brain-derived neurotrophic factor 
      protein expression.
PG  - 606-10
LID - 10.1097/WNR.0b013e32832a0a98 [doi]
AB  - Recent studies showed that dopamine or D1 receptor-selective agonists increased 
      brain-derived neurotrophic factor (BDNF) mRNA and protein expression in neuronal 
      cultures, and this action was blocked by SCH23390. Moreover, SKF38393 activated 
      Trk receptors and downstream signaling in striatal neurons. This study examined 
      whether dopamine agonists induce the expression of BDNF protein in rat brain 
      tissue. Acute slice preparations were incubated with dopamine agonists in 
      Hibernate A medium and BDNF protein was measured by a sensitive enzyme-linked 
      immunosorbent assay. Results showed that dopamine increased BDNF in tissue slices 
      after 24 h of incubation. Furthermore, SKF38393 produced a significant increase 
      in BDNF protein in striatal and hippocampal tissue slices. These findings suggest 
      that the induction of BDNF expression may constitute a downstream response to 
      D1-like dopamine receptor activation.
FAU - Williams, Stacey N
AU  - Williams SN
AD  - Department of Pharmaceutical Sciences, University of Maryland School of Pharmacy, 
      Baltimore, Maryland, USA.
FAU - Undieh, Ashiwel S
AU  - Undieh AS
LA  - eng
GR  - R01 DA017614/DA/NIDA NIH HHS/United States
GR  - R01 DA017614-03S1/DA/NIDA NIH HHS/United States
GR  - R01 DA017614-04/DA/NIDA NIH HHS/United States
GR  - DA017614/DA/NIDA NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PL  - England
TA  - Neuroreport
JT  - Neuroreport
JID - 9100935
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Dopamine Agonists)
RN  - 0 (Receptors, Dopamine D1)
RN  - 20OP60125T (Quinpirole)
RN  - 67287-49-4 (2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine)
RN  - VTD58H1Z2X (Dopamine)
SB  - IM
MH  - 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine/pharmacology
MH  - Analysis of Variance
MH  - Animals
MH  - Brain-Derived Neurotrophic Factor/*metabolism
MH  - Corpus Striatum/drug effects/*metabolism
MH  - Dopamine/metabolism
MH  - Dopamine Agonists/pharmacology
MH  - Enzyme-Linked Immunosorbent Assay
MH  - Frontal Lobe/drug effects/*metabolism
MH  - Hippocampus/drug effects/*metabolism
MH  - In Vitro Techniques
MH  - Male
MH  - Quinpirole/pharmacology
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Receptors, Dopamine D1/*metabolism
MH  - Time Factors
PMC - PMC2834182
MID - NIHMS179225
EDAT- 2009/03/20 09:00
MHDA- 2009/06/17 09:00
PMCR- 2010/04/22
CRDT- 2009/03/20 09:00
PHST- 2009/03/20 09:00 [entrez]
PHST- 2009/03/20 09:00 [pubmed]
PHST- 2009/06/17 09:00 [medline]
PHST- 2010/04/22 00:00 [pmc-release]
AID - 10.1097/WNR.0b013e32832a0a98 [doi]
PST - ppublish
SO  - Neuroreport. 2009 Apr 22;20(6):606-10. doi: 10.1097/WNR.0b013e32832a0a98.