PMID- 19296503
OWN - NLM
STAT- MEDLINE
DCOM- 20090601
LR  - 20211020
IS  - 0148-639X (Print)
IS  - 1097-4598 (Electronic)
IS  - 0148-639X (Linking)
VI  - 39
IP  - 4
DP  - 2009 Apr
TI  - Lean and obese Zucker rats exhibit different patterns of p70s6 kinase regulation 
      in the tibialis anterior muscle in response to high-force muscle contraction.
PG  - 503-11
LID - 10.1002/mus.21255 [doi]
AB  - Increased phosphorylation of the 70-kDa ribosomal S6 kinase (p70S6k) signaling is 
      strongly correlated with the degree of muscle adaptation following exercise. 
      Herein we compare the phosphorylation of p70S6k, Akt, and mammalian target of 
      rapamycin (mTOR) in the tibialis anterior (TA) muscles of lean and obese Zucker 
      rats following a bout of eccentric exercise. Exercise increased p70S6k (Thr389) 
      phosphorylation immediately after (33.3+/-7.2%) and during [1 h (24.0+/-14.9%) 
      and 3 h (24.6+/-11.3%)] recovery in the lean TA and at 3 h (33.5+/-8.0%) in the 
      obese TA Zucker rats. mTOR (Ser2448) phosphorylation was elevated in the lean TA 
      immediately after exercise (96.5+/-40.3%) but remained unaltered in the obese TA. 
      Exercise increased Akt (Thr308) and Akt (Ser473) phosphorylation in the lean but 
      not the obese TA. These results suggest that insulin resistance is associated 
      with alterations in the ability of muscle to activate p70S6k signaling following 
      an acute bout of exercise.
FAU - Katta, Anjaiah
AU  - Katta A
AD  - Department of Pharmacology, Physiology, and Toxicology, Marshall University, Joan 
      C. Edwards School of Medicine, Huntington, West Virginia, USA.
FAU - Karkala, Sunil K
AU  - Karkala SK
FAU - Wu, Miaozong
AU  - Wu M
FAU - Meduru, Sarath
AU  - Meduru S
FAU - Desai, Devashish H
AU  - Desai DH
FAU - Rice, Kevin M
AU  - Rice KM
FAU - Blough, Eric R
AU  - Blough ER
LA  - eng
GR  - R15 AG027103/AG/NIA NIH HHS/United States
GR  - R15 AG027103-01/AG/NIA NIH HHS/United States
GR  - AG-027103-1/AG/NIA NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PL  - United States
TA  - Muscle Nerve
JT  - Muscle & nerve
JID - 7803146
RN  - 0 (Insulin)
RN  - EC 2.7.11.1 (Ribosomal Protein S6 Kinases, 70-kDa)
SB  - IM
MH  - Animals
MH  - Body Weight
MH  - Electric Stimulation
MH  - Insulin/physiology
MH  - Insulin Resistance/*physiology
MH  - Male
MH  - Muscle Contraction/*physiology
MH  - Muscle, Skeletal/anatomy & histology/innervation/*physiology
MH  - Obesity/*metabolism/*physiopathology
MH  - Organ Size
MH  - Phosphorylation/physiology
MH  - Physical Exertion/physiology
MH  - Rats
MH  - Rats, Zucker
MH  - Ribosomal Protein S6 Kinases, 70-kDa/*metabolism
MH  - Sciatic Nerve/physiology
MH  - Signal Transduction/physiology
PMC - PMC2803764
MID - NIHMS119995
EDAT- 2009/03/20 09:00
MHDA- 2009/06/02 09:00
PMCR- 2010/01/09
CRDT- 2009/03/20 09:00
PHST- 2009/03/20 09:00 [entrez]
PHST- 2009/03/20 09:00 [pubmed]
PHST- 2009/06/02 09:00 [medline]
PHST- 2010/01/09 00:00 [pmc-release]
AID - 10.1002/mus.21255 [doi]
PST - ppublish
SO  - Muscle Nerve. 2009 Apr;39(4):503-11. doi: 10.1002/mus.21255.