PMID- 19298207
OWN - NLM
STAT- MEDLINE
DCOM- 20090529
LR  - 20131121
IS  - 1557-7600 (Electronic)
IS  - 1096-620X (Linking)
VI  - 12
IP  - 1
DP  - 2009 Feb
TI  - Methionine-induced hyperhomocysteinemia modulates lipoprotein profile and 
      oxidative stress but not progression of atherosclerosis in aged apolipoprotein E 
      knockout mice.
PG  - 137-44
LID - 10.1089/jmf.2007.0561 [doi]
AB  - It is documented that hyperhomocysteinemia (HHcy) is an independent risk factor 
      for atherosclerosis, but whether elevated plasma homocysteine contributes to the 
      progression of atherosclerosis in aged animals with hypercholesterolemia is still 
      unknown. HHcy was induced in apolipoprotein E (ApoE) knockout mice (male, 32 
      weeks old) by feeding 2% methionine/low folate (1 mg/kg) diet for 20 weeks. HHcy 
      induced by methionine feeding significantly increased oxidative stress, as 
      measured by thiobarbituric-reactive substances in livers (P < .05) and genetic 
      expression of Cu,Zn-superoxide dismutase, in methionine-fed animals compared with 
      controls (P < .05). Furthermore, lipoprotein profiles were changed, in that 
      low-density lipoprotein-cholesterol was shifted to very low-density lipoprotein 
      in the methionine-supplemented group. However, nuclear factor kappaB activity, 
      atherosclerotic lesions, hepatic glutathione level, lipid profiles, and 
      activities of aspartate aminotransferase and alanine aminotransferase were not 
      significantly different. These findings suggest that HHcy induced by methionine 
      may promote disturbances in lipid peroxidation and modify lipoprotein metabolism 
      but not contribute to the progression of atherosclerotic lesion in aged ApoE 
      knockout mice.
FAU - Song, Youngsun
AU  - Song Y
AD  - Center of Smart Food & Drug, Food Science Institute, Inje University, Gyongnam, 
      Republic of Korea. fdsnsong@inje.ac.kr
FAU - Cho, Mikyung
AU  - Cho M
FAU - Cho, Chungwon
AU  - Cho C
FAU - Rosenfeld, Michael E
AU  - Rosenfeld ME
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Med Food
JT  - Journal of medicinal food
JID - 9812512
RN  - 0 (Antioxidants)
RN  - 0 (Apolipoproteins E)
RN  - 0 (Lipoproteins)
RN  - 0 (NF-kappa B)
RN  - 0 (RNA, Messenger)
RN  - 935E97BOY8 (Folic Acid)
RN  - 97C5T2UQ7J (Cholesterol)
RN  - AE28F7PNPL (Methionine)
RN  - EC 2.6.1.1 (Aspartate Aminotransferases)
RN  - EC 2.6.1.2 (Alanine Transaminase)
RN  - GAN16C9B8O (Glutathione)
SB  - IM
MH  - Alanine Transaminase/metabolism
MH  - Animals
MH  - Antioxidants/metabolism
MH  - Apolipoproteins E/genetics
MH  - Aspartate Aminotransferases/metabolism
MH  - Atherosclerosis/*etiology
MH  - Cholesterol/blood
MH  - Folic Acid/pharmacology
MH  - Glutathione/metabolism
MH  - Hyperhomocysteinemia/chemically induced/*complications/metabolism
MH  - Lipoproteins/*blood
MH  - Male
MH  - Methionine
MH  - Mice
MH  - Mice, Knockout
MH  - NF-kappa B/metabolism
MH  - Oxidative Stress
MH  - RNA, Messenger/metabolism
EDAT- 2009/03/21 09:00
MHDA- 2009/05/30 09:00
CRDT- 2009/03/21 09:00
PHST- 2009/03/21 09:00 [entrez]
PHST- 2009/03/21 09:00 [pubmed]
PHST- 2009/05/30 09:00 [medline]
AID - 10.1089/jmf.2007.0561 [doi]
PST - ppublish
SO  - J Med Food. 2009 Feb;12(1):137-44. doi: 10.1089/jmf.2007.0561.