PMID- 19298230
OWN - NLM
STAT- MEDLINE
DCOM- 20091030
LR  - 20220317
IS  - 1365-2982 (Electronic)
IS  - 1350-1925 (Linking)
VI  - 21
IP  - 8
DP  - 2009 Aug
TI  - Inhibitory effect of oxytocin on accelerated colonic motility induced by 
      water-avoidance stress in rats.
PG  - 856-e59
LID - 10.1111/j.1365-2982.2009.01286.x [doi]
AB  - Recent studies have indicated that brain and gut activities are interrelated and 
      exposure to several stressors, such as water-avoidance stress, stimulates the 
      motor function of the gut through corticotropin-releasing factor (CRF)-signalling 
      pathways in the brain. Central oxytocin is known to attenuate stress responses, 
      including CRF expression in the brain. Here, we examined whether central oxytocin 
      attenuated the acceleration of colonic motility induced by water-avoidance 
      stress. A force transducer was attached to the distal colon of male rat, and the 
      colonic motility and faecal pellet output were recorded while the rats were 
      exposed to water-avoidance stress. Intracerebroventricular (i.c.v.) injections of 
      oxytocin (5, 50 and 500 pmol) and the oxytocin receptor antagonist tocinoic acid 
      (25 microg) were administered before exposure to water-avoidance stress, and the 
      effect of oxytocin on colonic motor function was determined. Centrally 
      administered oxytocin inhibited the accelerated colonic motility induced by 
      water-avoidance stress. The effective dose ranged between 5 and 50 pmol on i.c.v. 
      injection. Oxytocin also decreased the number of CRF-positive cells in the 
      paraventricular nucleus and corticosterone release. The inhibitory effect of 
      oxytocin on accelerated colonic motility was blocked by pretreatment with 
      oxytocin receptor antagonist. Furthermore, centrally administered tocinoic acid 
      enhanced the acceleration of colonic motility. These results suggested that 
      endogenous central oxytocin may contribute to the regulation of colonic function 
      and inhibit the brain CRF-signalling pathways targeting the gut, resulting in the 
      inhibition of stress-induced colonic contractions.
FAU - Matsunaga, M
AU  - Matsunaga M
AD  - Department of Neurology, Ban Buntane Hotokukai Hospital, Fujita Health 
      University, Aichi, Japan.
FAU - Konagaya, T
AU  - Konagaya T
FAU - Nogimori, T
AU  - Nogimori T
FAU - Yoneda, M
AU  - Yoneda M
FAU - Kasugai, K
AU  - Kasugai K
FAU - Ohira, H
AU  - Ohira H
FAU - Kaneko, H
AU  - Kaneko H
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20090309
PL  - England
TA  - Neurogastroenterol Motil
JT  - Neurogastroenterology and motility
JID - 9432572
RN  - 50-56-6 (Oxytocin)
RN  - 9015-71-8 (Corticotropin-Releasing Hormone)
SB  - IM
MH  - Animals
MH  - *Colon/drug effects/physiology
MH  - Corticotropin-Releasing Hormone/metabolism
MH  - *Gastrointestinal Motility/drug effects/physiology
MH  - Injections, Intraventricular
MH  - Male
MH  - Oxytocin/administration & dosage/analogs & derivatives/*pharmacology
MH  - Paraventricular Hypothalamic Nucleus/metabolism
MH  - Rats
MH  - Rats, Wistar
MH  - *Stress, Psychological
EDAT- 2009/03/21 09:00
MHDA- 2009/10/31 06:00
CRDT- 2009/03/21 09:00
PHST- 2009/03/21 09:00 [entrez]
PHST- 2009/03/21 09:00 [pubmed]
PHST- 2009/10/31 06:00 [medline]
AID - NMO1286 [pii]
AID - 10.1111/j.1365-2982.2009.01286.x [doi]
PST - ppublish
SO  - Neurogastroenterol Motil. 2009 Aug;21(8):856-e59. doi: 
      10.1111/j.1365-2982.2009.01286.x. Epub 2009 Mar 9.