PMID- 19298239
OWN - NLM
STAT- MEDLINE
DCOM- 20091001
LR  - 20090729
IS  - 1399-3062 (Electronic)
IS  - 1398-2273 (Linking)
VI  - 11
IP  - 3
DP  - 2009 Jun
TI  - Infectious complications after allogeneic stem cell transplantation: incidence in 
      matched-related and matched-unrelated transplant settings.
PG  - 220-6
LID - 10.1111/j.1399-3062.2009.00379.x [doi]
AB  - BACKGROUND: Bacterial, viral, and fungal pathogens frequently cause severe, 
      life-threatening infections in immunocompromised patients after allogeneic 
      hematopoietic stem cell transplantation (SCT). OBJECTIVE: To compare the 
      frequency of infections in patients with matched-related (Group A) or with human 
      leukocyte antigen (HLA)-matched-unrelated donors (Group B). PATIENTS AND METHODS: 
      Patients treated at our transplantation unit between April 2004 and April 2005 
      were enrolled into this analysis. Documentation comprised demographic data, 
      conditioning treatment, stem cell source, clinical course, as well as 
      microbiological and clinical data and mortality. RESULTS: We analyzed 59 
      patients, 22 in Group A and 37 in Group B. Both groups were well balanced 
      regarding demographic data. Diagnoses were acute myeloid leukemia (30 of 59 
      patients, 50.8%), multiple myeloma (15.2%), acute lymphoblastic leukemia (11.9%), 
      and chronic myeloid leukemia (10.2%). Patients in Group A developed infections in 
      95.5% of the cases compared with 97.3% in patients in Group B. Most frequently 
      detected pathogens were Staphylococcus species, human herpesvirus-6, and 
      Epstein-Barr virus. Three proven fungal infections were detected in Group A 
      compared with 9 proven fungal infections in Group B. Lung infiltrations were 
      observed in equivalent incidence in both groups. Two years after transplantation, 
      55.9% of patients were alive (Group A: 68.2%; Group B: 48.6%, not significant). 
      CONCLUSION: Allogeneic SCT from HLA-matched-unrelated donors does not have a 
      higher infection risk than patients transplanted from matched-related donors.
FAU - Rieger, C T
AU  - Rieger CT
AD  - Department of Hematology/Oncology, University of Munich Campus Grosshadern, 
      Munich, Germany. christina.rieger@med.uni-muenchen.de
FAU - Rieger, H
AU  - Rieger H
FAU - Kolb, H J
AU  - Kolb HJ
FAU - Peterson, L
AU  - Peterson L
FAU - Huppmann, S
AU  - Huppmann S
FAU - Fiegl, M
AU  - Fiegl M
FAU - Ostermann, H
AU  - Ostermann H
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20090309
PL  - Denmark
TA  - Transpl Infect Dis
JT  - Transplant infectious disease : an official journal of the Transplantation 
      Society
JID - 100883688
SB  - IM
MH  - Adult
MH  - Bacterial Infections/diagnosis/*epidemiology/etiology
MH  - *Donor Selection
MH  - Female
MH  - Histocompatibility Testing
MH  - Humans
MH  - Incidence
MH  - Male
MH  - Middle Aged
MH  - Mycoses/diagnosis/*epidemiology/etiology
MH  - Risk Assessment
MH  - Stem Cell Transplantation/*adverse effects
MH  - Transplantation, Homologous/*adverse effects
MH  - Virus Diseases/diagnosis/*epidemiology/etiology
EDAT- 2009/03/21 09:00
MHDA- 2009/10/02 06:00
CRDT- 2009/03/21 09:00
PHST- 2009/03/21 09:00 [entrez]
PHST- 2009/03/21 09:00 [pubmed]
PHST- 2009/10/02 06:00 [medline]
AID - TID379 [pii]
AID - 10.1111/j.1399-3062.2009.00379.x [doi]
PST - ppublish
SO  - Transpl Infect Dis. 2009 Jun;11(3):220-6. doi: 10.1111/j.1399-3062.2009.00379.x. 
      Epub 2009 Mar 9.