PMID- 19298720
OWN - NLM
STAT- MEDLINE
DCOM- 20090902
LR  - 20090320
IS  - 1607-8454 (Electronic)
IS  - 1024-5332 (Linking)
VI  - 14
IP  - 2
DP  - 2009 Apr
TI  - Fluorescent in situ hybridization studies in multiple myeloma.
PG  - 90-4
LID - 10.1179/102453309X385250 [doi]
AB  - Conventional cytogenetic analysis and fluorescence in situ hybridization (FISH) 
      results of bone marrow samples of 36 multiple myeloma (MM) patients at the time 
      of diagnosis have been evaluated. Three probes for chromosome 13q (RB1, D13S319, 
      D13S25), one for 14q32 (IgH) and one for 17p13 (p53) have been used for 
      hybridization with fixed cells. Twenty patients (55.5%) had normal karyotypes, 
      whereas eight (22.2%) had numerical or structural chromosomal abnormalities. We 
      did not find metaphases for chromosome analysis in eight (22.2%) patients. 
      Fluorescence in situ hybridization analyses revealed at least one or more 
      abnormal results in 25 (69.5%) cases, whereas 11(30.5%) cases had no abnormal 
      findings. 14q32 rearrangement was the most common finding in FISH analyses and 
      has been detected in 21 cases (58.3%). 13q deletion and 17p deletion have been 
      detected in 11 (30.5%) and 5 (13.9%) cases, respectively. Fluorescence in situ 
      hybridization studies including 14q32 and 17p13 chromosome regions may yield 
      quite significant results during clinical follow-up of MM.
FAU - Yuregir, Ozge Ozalp
AU  - Yuregir OO
AD  - Department of Medical Genetics, Baskent University Faculty of Medicine, Kubilay 
      Sokak No. 36, Maltepe, Ankara, Turkey.
FAU - Sahin, Feride Iffet
AU  - Sahin FI
FAU - Yilmaz, Zerrin
AU  - Yilmaz Z
FAU - Kizilkilic, Ebru
AU  - Kizilkilic E
FAU - Karakus, Sema
AU  - Karakus S
FAU - Ozdogu, Hakan
AU  - Ozdogu H
LA  - eng
PT  - Journal Article
PL  - England
TA  - Hematology
JT  - Hematology (Amsterdam, Netherlands)
JID - 9708388
SB  - IM
MH  - Adult
MH  - Aged
MH  - Bone Marrow Cells/pathology
MH  - Chromosome Aberrations
MH  - Chromosomes, Human, Pair 13
MH  - Chromosomes, Human, Pair 14
MH  - Chromosomes, Human, Pair 17
MH  - Cytogenetic Analysis/methods
MH  - Female
MH  - Humans
MH  - In Situ Hybridization, Fluorescence/methods
MH  - Male
MH  - Middle Aged
MH  - Multiple Myeloma/*genetics/pathology
EDAT- 2009/03/21 09:00
MHDA- 2009/09/03 06:00
CRDT- 2009/03/21 09:00
PHST- 2009/03/21 09:00 [entrez]
PHST- 2009/03/21 09:00 [pubmed]
PHST- 2009/09/03 06:00 [medline]
AID - 10.1179/102453309X385250 [doi]
PST - ppublish
SO  - Hematology. 2009 Apr;14(2):90-4. doi: 10.1179/102453309X385250.