PMID- 19298795
OWN - NLM
STAT- MEDLINE
DCOM- 20090706
LR  - 20220113
IS  - 1873-3492 (Electronic)
IS  - 0009-8981 (Linking)
VI  - 403
IP  - 1-2
DP  - 2009 May
TI  - The IL-16 gene polymorphisms and the risk of the systemic lupus erythematosus.
PG  - 223-5
LID - 10.1016/j.cca.2009.03.016 [doi]
AB  - BACKGROUND: Interleukin 16 (IL-16) is an immunomodulatory cytokine which plays an 
      important role in many inflammatory and autoimmune diseases. We determined the 
      association between SNPs of IL-16 gene (i.e. rs11556218 G/T, rs4778889 C/T, and 
      rs4072111 C/T) and systemic lupus erythematosus (SLE). METHODS: One hundred 
      thirty-eight SLE patients and 199 controls were genotyped by polymerase chain 
      reaction-restriction fragment length polymorphism (PCR-RFLP) and DNA sequencing 
      assay. RESULTS: In the SLE group, the individuals carrying the G allele of 
      rs11556218, the C allele of rs4778889 and the T allele of rs4072111 are at a 
      significantly higher risk of SLE as compared with those carrying the T allele of 
      rs11556218, the T allele of rs4778889, and the C allele of rs4072111 respectively 
      (for rs11556218, OR=2.264, 95% CI, 1.64-3.127; for rs4778889, OR=1.927, 95%CI, 
      1.359-2.731; and for rs4072111, OR=2.417, 95% CI, 1.691-3.455). CONCLUSIONS: The 
      IL-16 gene polymorphisms may be associated with the risk of SLE.
FAU - Xue, Hui
AU  - Xue H
AD  - Department of Immunology, West China School of Preclinical and Forensic Medicine, 
      Sichuan University, Chengdu, 610041, Sichuan, PR China.
FAU - Gao, Linbo
AU  - Gao L
FAU - Wu, Yongkang
AU  - Wu Y
FAU - Fang, Wenliang
AU  - Fang W
FAU - Wang, Lanlan
AU  - Wang L
FAU - Li, Cui
AU  - Li C
FAU - Li, Yi
AU  - Li Y
FAU - Liang, Weibo
AU  - Liang W
FAU - Zhang, Lin
AU  - Zhang L
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20090317
PL  - Netherlands
TA  - Clin Chim Acta
JT  - Clinica chimica acta; international journal of clinical chemistry
JID - 1302422
RN  - 0 (Interleukin-16)
SB  - IM
MH  - Adult
MH  - Female
MH  - Gene Frequency
MH  - *Genetic Predisposition to Disease
MH  - Genotype
MH  - Humans
MH  - Interleukin-16/*genetics
MH  - Lupus Erythematosus, Systemic/*genetics
MH  - Male
MH  - *Polymorphism, Genetic
EDAT- 2009/03/21 09:00
MHDA- 2009/07/07 09:00
CRDT- 2009/03/21 09:00
PHST- 2009/02/05 00:00 [received]
PHST- 2009/03/11 00:00 [revised]
PHST- 2009/03/11 00:00 [accepted]
PHST- 2009/03/21 09:00 [entrez]
PHST- 2009/03/21 09:00 [pubmed]
PHST- 2009/07/07 09:00 [medline]
AID - S0009-8981(09)00148-X [pii]
AID - 10.1016/j.cca.2009.03.016 [doi]
PST - ppublish
SO  - Clin Chim Acta. 2009 May;403(1-2):223-5. doi: 10.1016/j.cca.2009.03.016. Epub 
      2009 Mar 17.