PMID- 19299045
OWN - NLM
STAT- MEDLINE
DCOM- 20100202
LR  - 20161018
IS  - 1768-3122 (Electronic)
IS  - 0248-8663 (Linking)
VI  - 30
IP  - 11
DP  - 2009 Nov
TI  - [Antidepressant use in demented elderly subjects: current data].
PG  - 947-54
LID - 10.1016/j.revmed.2009.01.023 [doi]
AB  - Depression and behavioural and psychological symptoms of dementia (BPSD) have a 
      significant impact on the worsening of dementia because they increase the 
      cognitive and functional decline and they have a significant impact on the vital 
      prognosis. Physicians should be particularly careful in the use of 
      antidepressants in the elderly, particularly in the frail elderly. Indeed, most 
      studies have included patients aged at least 65 years without frailty criteria, 
      but rarely those aged over 75 years and/or frail. As they are used in clinical 
      practice, selective serotonin reuptake inhibitors, which initially appeared to 
      have low risks, have been associated with many and dangerous adverse effects, 
      particularly in elderly subjects. At present, there is a lack of data to assess 
      the benefit-risk ratio of antidepressants in the treatment of depression and BPSD 
      in patients with Alzheimer's disease or other dementias. Among the drugs 
      frequently used in studies in order to evaluate these indications, citalopram and 
      moclobemide are those associated with a low risk of adverse events and a 
      significant effectiveness on depression signs and behavioural and BPSD. It is 
      necessary to assess the effectiveness and adverse effects of antidepressants in 
      demented elderly subjects through several studies.
FAU - Belicard-Pernot, C
AU  - Belicard-Pernot C
AD  - Service de medecine interne geriatrie, centre de Champmaillot, CHU de Dijon, 2 
      rue Jules-Violle, Dijon cedex, France.
FAU - Manckoundia, P
AU  - Manckoundia P
FAU - Ponavoy, E
AU  - Ponavoy E
FAU - Rouaud, O
AU  - Rouaud O
FAU - Pfitzenmeyer, P
AU  - Pfitzenmeyer P
LA  - fre
PT  - English Abstract
PT  - Journal Article
PT  - Review
TT  - Utilisation des antidepresseurs chez les sujets ages dements: donnees actuelles.
DEP - 20090318
PL  - France
TA  - Rev Med Interne
JT  - La Revue de medecine interne
JID - 8101383
RN  - 0 (Antidepressive Agents)
SB  - IM
MH  - Aged
MH  - Antidepressive Agents/adverse effects/*therapeutic use
MH  - Dementia/*complications
MH  - Depression/*drug therapy/*etiology
MH  - Humans
RF  - 74
EDAT- 2009/03/21 09:00
MHDA- 2010/02/03 06:00
CRDT- 2009/03/21 09:00
PHST- 2008/09/25 00:00 [received]
PHST- 2009/01/20 00:00 [revised]
PHST- 2009/01/31 00:00 [accepted]
PHST- 2009/03/21 09:00 [entrez]
PHST- 2009/03/21 09:00 [pubmed]
PHST- 2010/02/03 06:00 [medline]
AID - S0248-8663(09)00083-6 [pii]
AID - 10.1016/j.revmed.2009.01.023 [doi]
PST - ppublish
SO  - Rev Med Interne. 2009 Nov;30(11):947-54. doi: 10.1016/j.revmed.2009.01.023. Epub 
      2009 Mar 18.