PMID- 19300570
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20110222
LR  - 20211020
IS  - 1176-6328 (Print)
IS  - 1178-2021 (Electronic)
IS  - 1176-6328 (Linking)
VI  - 3
IP  - 4
DP  - 2007 Aug
TI  - Levetiracetam in the treatment of childhood epilepsy.
PG  - 409-21
AB  - Epilepsy is a common pediatric neurologic disorder that is difficult to manage in 
      a substantial portion of children. Levetiracetam (LEV) is a novel antiepileptic 
      drug (AED) that has recently been approved as add-on treatment for various 
      seizure types in epilepsy populations that include children: for refractory 
      partial seizures in epilepsy patients >/=4 years old, for myoclonic seizures in 
      juvenile myoclonic epilepsy patients >/=12 years old, and for primary generalized 
      tonic-clonic seizures in idiopathic generalized epilepsy patients (>/=6 years old 
      with FDA approval; >/=12 years old with EMEA approval). A review of published 
      pediatric studies indicates that the efficacy of LEV is best established for 
      partial seizures; however, results from recent double-blind and open-label trials 
      indicate that adjunctive LEV also controls generalized seizures - particularly 
      myoclonic and generalized tonic-clonic - in children and adolescents with primary 
      generalized epilepsy. LEV was well-tolerated in pediatric studies. The most 
      common adverse events (AEs) reported were sedation related. Behavioral AEs were 
      among the most commonly reported events in some trials; conversely, improvements 
      in behavior and cognition were also frequently reported. LEV appears to be a safe 
      and effective AED with unique characteristics that benefit the treatment of 
      children with epilepsy.
FAU - Wheless, James W
AU  - Wheless JW
AD  - Pediatric Neurology, University of Tennessee Health Science Center; Neuroscience 
      Institute, LeBonheur Children's Medical Center, Memphis, TN, USA. 
      jwheless@utmem.edu
LA  - eng
PT  - Journal Article
PL  - New Zealand
TA  - Neuropsychiatr Dis Treat
JT  - Neuropsychiatric disease and treatment
JID - 101240304
PMC - PMC2655081
OTO - NOTNLM
OT  - children
OT  - epilepsy
OT  - levetiracetam
OT  - seizures
EDAT- 2007/08/01 00:00
MHDA- 2007/08/01 00:01
PMCR- 2007/12/01
CRDT- 2009/03/21 09:00
PHST- 2009/03/21 09:00 [entrez]
PHST- 2007/08/01 00:00 [pubmed]
PHST- 2007/08/01 00:01 [medline]
PHST- 2007/12/01 00:00 [pmc-release]
AID - ndt-3-409 [pii]
PST - ppublish
SO  - Neuropsychiatr Dis Treat. 2007 Aug;3(4):409-21.