PMID- 19300615
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20110517
LR  - 20211020
IS  - 1176-6328 (Print)
IS  - 1178-2021 (Electronic)
IS  - 1176-6328 (Linking)
VI  - 3
IP  - 6
DP  - 2007 Dec
TI  - Almotriptan in the treatment of migraine.
PG  - 799-809
AB  - Almotriptan is an orally administered, highly selective serotonin 5-HT(1(B)/1(D)) 
      receptor agonist that is effective in the acute treatment of moderate to severe 
      migraine attacks. Since its introduction on to the market in 2001, several 
      studies involving a large number of migraine patients have confirmed its efficacy 
      and tolerability profile. Almotriptan, was found to be among the best-responding 
      triptans in terms of pain relief and pain-free rate at 2 h. It has been reported 
      that almotriptan has the best sustained pain-free (SPF) rate and the lowest 
      adverse events (AEs) rate of all the triptans. When these clinical 
      characteristics were combined to form the composite endpoint SPF and no AEs 
      (SNAE), almotriptan emerged as the triptan with the best efficacy and 
      tolerability profile. It also showed a good efficacy profile during the early 
      treatment (within 1 h of onset) of migraine attacks characterized by moderate 
      pain intensity. On the basis of these findings, almotriptan may be considered a 
      therapeutic option for the acute treatment of migraine attacks.
FAU - Sandrini, Giorgio
AU  - Sandrini G
AD  - University Centre for Adaptive, Disorders and Headache, IRCCS, "C. Mondino 
      Institute of Neurology" Foundation, University of Pavia, Pavia, Italy.
FAU - Perrotta, Armando
AU  - Perrotta A
FAU - Arce Leal, Natalia L
AU  - Arce Leal NL
FAU - Buscone, Simona
AU  - Buscone S
FAU - Nappi, Giuseppe
AU  - Nappi G
LA  - eng
PT  - Journal Article
PL  - New Zealand
TA  - Neuropsychiatr Dis Treat
JT  - Neuropsychiatric disease and treatment
JID - 101240304
PMC - PMC2656322
OTO - NOTNLM
OT  - almotriptan
OT  - migraine
OT  - treatment
OT  - triptans
EDAT- 2007/12/01 00:00
MHDA- 2007/12/01 00:01
PMCR- 2008/04/01
CRDT- 2009/03/21 09:00
PHST- 2009/03/21 09:00 [entrez]
PHST- 2007/12/01 00:00 [pubmed]
PHST- 2007/12/01 00:01 [medline]
PHST- 2008/04/01 00:00 [pmc-release]
AID - ndt-3-799 [pii]
AID - 10.2147/ndt.s487 [doi]
PST - ppublish
SO  - Neuropsychiatr Dis Treat. 2007 Dec;3(6):799-809. doi: 10.2147/ndt.s487.