PMID- 19302553
OWN - NLM
STAT- MEDLINE
DCOM- 20090608
LR  - 20161125
IS  - 1474-8673 (Electronic)
IS  - 1474-8665 (Linking)
VI  - 29
IP  - 1-2
DP  - 2009 Jan
TI  - Influence of high dietary sodium intake on the functional subtypes of 
      alpha-adrenoceptors in the renal cortical vasculature of Wistar-Kyoto rats.
PG  - 25-31
LID - 10.1111/j.1474-8673.2009.00428.x [doi]
AB  - 1 Increased renal vascular resistance is one renal functional abnormality that 
      contributes to hypertension, and alpha(1)-adrenoceptors play a pivotal role in 
      modulating this renal vascular resistance. This study investigates the functional 
      contribution of alpha(1)-adrenoceptor subtypes in the renal cortical vasculature 
      of Wistar-Kyoto rats on a normal sodium diet (WKYNNa) compared with those given 
      saline to drink for 6 weeks (WKYHNa). 2 The renal cortical vascular responses to 
      the adrenergic agonists noradrenaline (NA), methoxamine (ME) and phenylephrine 
      (PE) were measured in WKYHNa and WKYNNa rats either in the absence (the control 
      phase) or presence of chloroethylclonidine (CEC), an alpha(1B)-adrenoceptor 
      antagonist, 5-methylurapidil (5-MeU), an alpha(1A) antagonist, or BMY7378, an 
      alpha(1D) antagonist. 3 Results showed a greater renal cortical vascular 
      sensitivity to NA, PE and ME in the WKYHNa compared with WKYNNa rats (P < 0.05). 
      Moreover, 5-MeU and BMY7378 attenuated adrenergically induced renal cortical 
      vasoconstriction in WKYHNa and WKYNNa rats; this response was largely blunted in 
      CEC-treated WKYHNa rats (all P < 0.05) but not in CEC-treated WKYNNa rats. 4 The 
      data suggest that irrespective of dietary sodium content, in Wistar-Kyoto rats 
      alpha(1A)- and alpha(1D)-subtypes are the major alpha(1)-adrenoceptors in renal 
      cortical vasculature; however, there appears to be a functional involvement of 
      alpha(1B)-adrenoceptors in the WKYHNa rats.
FAU - Kazi, R N
AU  - Kazi RN
AD  - University Sains Malaysia, Penang, Malaysia.
FAU - Munavvar, A S
AU  - Munavvar AS
FAU - Abdullah, N A
AU  - Abdullah NA
FAU - Khan, A H
AU  - Khan AH
FAU - Johns, E J
AU  - Johns EJ
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Auton Autacoid Pharmacol
JT  - Autonomic & autacoid pharmacology
JID - 101157306
RN  - 0 (Adrenergic alpha-1 Receptor Antagonists)
RN  - 0 (Adrenergic alpha-Antagonists)
RN  - 0 (Hydroxylamines)
RN  - 0 (Piperazines)
RN  - 0 (Receptors, Adrenergic, alpha-1)
RN  - 0 (Sodium, Dietary)
RN  - 0 (Vasoconstrictor Agents)
RN  - 1HLS600135 (5-methylurapidil)
RN  - 1WS297W6MV (Phenylephrine)
RN  - 3X825O680H (chlorethylclonidine)
RN  - 9NEZ333N27 (Sodium)
RN  - 9TZH4WY30J (methoxyamine)
RN  - KC07KV8T5O (BMY 7378)
RN  - MN3L5RMN02 (Clonidine)
RN  - X4W3ENH1CV (Norepinephrine)
SB  - IM
MH  - Adrenergic alpha-1 Receptor Antagonists
MH  - Adrenergic alpha-Antagonists/pharmacology
MH  - Animals
MH  - Blood Pressure/drug effects
MH  - Body Weight/drug effects
MH  - Clonidine/analogs & derivatives/pharmacology
MH  - Drinking/drug effects
MH  - Hydroxylamines/pharmacology
MH  - Kidney Cortex/*blood supply/*drug effects
MH  - Male
MH  - Norepinephrine/pharmacology
MH  - Phenylephrine/pharmacology
MH  - Piperazines/pharmacology
MH  - Rats
MH  - Rats, Inbred WKY
MH  - Receptors, Adrenergic, alpha-1/*drug effects/*physiology
MH  - Renal Circulation/drug effects/physiology
MH  - Sodium/urine
MH  - Sodium, Dietary/*administration & dosage/*pharmacology
MH  - Urine
MH  - Vasoconstriction/drug effects/*physiology
MH  - Vasoconstrictor Agents/pharmacology
EDAT- 2009/03/24 09:00
MHDA- 2009/06/09 09:00
CRDT- 2009/03/24 09:00
PHST- 2009/03/24 09:00 [entrez]
PHST- 2009/03/24 09:00 [pubmed]
PHST- 2009/06/09 09:00 [medline]
AID - AAP428 [pii]
AID - 10.1111/j.1474-8673.2009.00428.x [doi]
PST - ppublish
SO  - Auton Autacoid Pharmacol. 2009 Jan;29(1-2):25-31. doi: 
      10.1111/j.1474-8673.2009.00428.x.