PMID- 19303625
OWN - NLM
STAT- MEDLINE
DCOM- 20090618
LR  - 20161125
IS  - 0048-9697 (Print)
IS  - 0048-9697 (Linking)
VI  - 407
IP  - 12
DP  - 2009 Jun 1
TI  - Bioactivity of POPs and their effects in mosquitofish in Sydney Olympic Park, 
      Australia.
PG  - 3721-30
LID - 10.1016/j.scitotenv.2009.02.015 [doi]
AB  - The site of the 2000 Olympic Games (Sydney Olympic Park (SOP), Sydney, Australia) 
      was contaminated by persistent organic pollutants (POPs) prior to remediation in 
      the 1990s. This study investigates the bioactivity of POPs in the sediment and 
      water of wetlands across SOP by in vitro 2,3,7,8-TCDD equivalence (TCDDeq) 
      measurement (H4IIE cell line bioassay). Further, it examines whether disturbance 
      of these sediments is likely to mobilise ligands for this receptor into the water 
      column. Exposure to aryl hydrocarbon receptor (AhR) ligands was measured in vivo 
      using hepatic cytochrome P4501A (CYP1A) induction (EROD) in the mosquitofish 
      (Gambusia holbrooki). Aqueous TCDDeq ranged from 0.013 to 0.057 pM in SOP 
      wetlands which was significantly (p<0.05) less that in urban reference sites. 
      These concentrations were not correlated to physical or chemical characteristics 
      of the wetlands. In the sediments, TCDDeq ranged from 0.0016 to 7.06 microg/kg 
      and these were not significantly (p>or=0.05) different to that measured in urban 
      reference sites. Simulated disturbance of small quantities of sediment in water 
      samples significantly (p<0.05) increased the levels of TCDDeq measured in the 
      water. Sediment TCDDeq was correlated to sediment SigmaPAH concentration in 2006 
      and sediment SigmaPCB, SigmaDDT concentrations and fine sediment grain size in 
      2005. While fish at one SOP wetland had hepatic EROD activity elevated above the 
      estimated basal level for this species, these were at the lower end of the range 
      measured in urban impacted, non-remediated wetlands. EROD activity was positively 
      correlated with both the sediment SigmaPCB load and aqueous TCDDeq. Increased 
      catchment size was correlated with increased EROD activity suggesting an even 
      spread of POPs throughout the residential areas of the Sydney metropolitan area. 
      The concentration of bioactive POPs in the wetlands of SOP is therefore low 
      relative to urban reference sites demonstrating the ongoing success of the 
      remediation program.
FAU - Rawson, Christopher A
AU  - Rawson CA
AD  - Institute of Water and Environmental Resource Management (IWERM) and Department 
      of Environmental Sciences, University of Technology, Sydney (UTS), PO Box 123 
      Broadway, NSW 2001, Australia.
FAU - Tremblay, Louis A
AU  - Tremblay LA
FAU - Warne, Michael St J
AU  - Warne MS
FAU - Ying, Guang-Guo
AU  - Ying GG
FAU - Kookana, Rai
AU  - Kookana R
FAU - Laginestra, Edwina
AU  - Laginestra E
FAU - Chapman, John C
AU  - Chapman JC
FAU - Lim, Richard P
AU  - Lim RP
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20090320
PL  - Netherlands
TA  - Sci Total Environ
JT  - The Science of the total environment
JID - 0330500
RN  - 0 (Polychlorinated Dibenzodioxins)
RN  - 0 (Receptors, Aryl Hydrocarbon)
RN  - 0 (Water Pollutants, Chemical)
RN  - EC 1.14.14.1 (Cytochrome P-450 CYP1A1)
SB  - IM
MH  - Animals
MH  - Biodegradation, Environmental/drug effects
MH  - Cyprinodontiformes/*metabolism
MH  - Cytochrome P-450 CYP1A1/analysis
MH  - Environmental Exposure/adverse effects/analysis
MH  - Environmental Monitoring
MH  - Environmental Restoration and Remediation
MH  - Geologic Sediments/*chemistry
MH  - New South Wales
MH  - Polychlorinated Dibenzodioxins/analysis
MH  - Receptors, Aryl Hydrocarbon/analysis/metabolism
MH  - Rivers/*chemistry
MH  - Water Pollutants, Chemical/*analysis/metabolism
MH  - Wetlands
EDAT- 2009/03/24 09:00
MHDA- 2009/06/19 09:00
CRDT- 2009/03/24 09:00
PHST- 2008/12/16 00:00 [received]
PHST- 2009/02/10 00:00 [revised]
PHST- 2009/02/10 00:00 [accepted]
PHST- 2009/03/24 09:00 [entrez]
PHST- 2009/03/24 09:00 [pubmed]
PHST- 2009/06/19 09:00 [medline]
AID - S0048-9697(09)00172-7 [pii]
AID - 10.1016/j.scitotenv.2009.02.015 [doi]
PST - ppublish
SO  - Sci Total Environ. 2009 Jun 1;407(12):3721-30. doi: 
      10.1016/j.scitotenv.2009.02.015. Epub 2009 Mar 20.